A Skin Manifestation due to the Intraarterial Infusion of Epirubicin.

DOI 12 References
  • TERASAKI Kenjiro
    Department of Dermatology, Faculty of Medicine, Kagoshima University
  • MERA Yukari
    Department of Dermatology, Faculty of Medicine, Kagoshima University
  • BABA Chiaki
    Department of Dermatology, Faculty of Medicine, Kagoshima University
  • KANZAKI Tamotsu
    Department of Dermatology, Faculty of Medicine, Kagoshima University

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Other Title
  • Ｅｐｉｒｕｂｉｃｉｎ動注療法で生じた皮膚障害の１例

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Abstract

We report the findings of 56-year-old woman who experienced skin lesions on the regions corresponding to the arteries that had been infused with epirubicin for advanced breast cancer. The patient visited our department after developing erythema on her right anterior thorax after undergoing three weekly single arterial infusions of 70 mg of epirubicin into her right subclavian and internal thoracic arteries as preoperative therapy for right breast cancer. Well-demarcated erythema, pigmentation and necrotic ulcers were seen on the regions near the arteries. A biopsy of the erythema revealed necrotic changes in both the epidermis and sweat glands. Epirubicin is a doxorubicin (ADM) derivative developed to alleviate the side effects of ADM. In addition, it has recently been used in place of ADM in arterial infusions for local advanced breast cancer. The use of arterial chemotherapy is continually increasing due to advances in the development of intravascular catheters and arterial infusion reservoirs. We therefore believe that such cases, as the one described will increase in the near future.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 64 (3), 298-300, 2002

    Western Division of Japanese Dermatological Association

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