Computer Analysis of Inulin Plasma Clearance Curve in Conscious Cats
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- MIYAMOTO Kenji
- Angel Animal Hospital
Bibliographic Information
- Other Title
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- 猫におけるイヌリンクリアランス曲線のコンピュータ解析
- ネコ ニ オケル イヌリンクリアランス キョクセン ノ コンピュータ カイセキ
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Abstract
Plasma clearance of inulin for estimating glomerular filtration rate (GFR) was evaluated in 8 normal cats under a conscious condition. Areas under the clearance curve (AUC) were determined with 11 or 12 plasma samples by 2 common pharmacokinetic analyses, the two-compartment model (2-CM) and the computer generated nonlinear regression analysis (NLR). AUC was also determined by NLR in case where the number of samples was reduced to 6. There was no significant difference between AUCs determined by 2-CM and NLR with 6 samples and between the resulting AUCs and computed GFRs using inulin dosage. The regression line between AUCs determined by 2-CM and NLR with 6 samples and between computed GFRs using inulin dosage and the AUCs showed an excellent fitness based on p value and coefficient of determinations.
Journal
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- Journal of the Japan Veterinary Medical Association
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Journal of the Japan Veterinary Medical Association 51 (9), 511-515, 1998
Japan Veterinary Medical Association
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Details 詳細情報について
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- CRID
- 1390001204708211456
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- NII Article ID
- 130004051937
- 10018948564
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- NII Book ID
- AN00191857
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- COI
- 1:CAS:528:DyaK1cXmtFCqt7w%3D
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- ISSN
- 21860211
- 04466454
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- NDL BIB ID
- 4553910
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed