A Case of mos 47XXY/46XY Klinefelter's Syndrome with Refractory Leg Ulcers

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  • 難治性下腿潰ようをきたしたｍｏｓ４７ＸＸＹ／４６ＸＹ　Ｋｌｉｎｅｆｅｌｔｅｒ症候群の１例
  • 症例 難治性下腿潰瘍をきたしたmos47 XXY/46 XY Klinefelter症候群の1例
  • ショウレイ ナンジセイ カタイ カイヨウ オ キタシタ mos47 XXY 46 XY Klinefelter ショウコウグン ノ 1レイ

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Abstract

We report a 51-year-old male with refractory leg ulcers complicating Klinefelter's syndrome. Recurrent leg ulcers had occurred for 16 years. Although valvoplasties of both femoral veins were performed in 1999, the condition was not relieved. Therefore, the patient were referred to our department on April 15, 2003. Ulcers were noted on both ankles. Both eyes were separated. Gynecomastia, thin hirci and pubic hair, and atrophic testis and penis were noted. Chromosome karyotypes were mos 47 XXY/46 XY and he demonstrated elevated serum LH and FSH and decreased serum testosterone. After hospitalization, he was diagnosed as having Klinefelter's syndrome. Split-thickness graft was performed, and oral administration of fluoxymesterone 4 mg/day prescribed. The ulcers initially recovered and he was discharged on June 20. However, ulcers recurred when the patient neglected to take fluoxymesterone in mid-July. When compliance was restored, the ulcers neither expanded nor reduced.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 66 (6), 553-558, 2004

    Western Division of Japanese Dermatological Association

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