Puffy Erythemic Eyelids Caused by Amiodaron-induced Hypothyroidism Mimicking Dermatomyositis

DOI Web Site 18 References
  • YAMAMOTO Tetsuya
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry
  • OFUJI Reiko
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry
  • OONO Takashi
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry
  • IWATSUKI Keiji
    Department of Dermatology, Okayama University Graduate School of Medicine and Dentistry

Bibliographic Information

Other Title
  • 眼けん浮腫を呈し，皮膚筋炎と鑑別を要したアミオダロン誘発性甲状腺機能低下症
  • 症例 眼瞼浮腫を呈し,皮膚筋炎と鑑別を要したアミオダロン誘発性甲状腺機能低下症
  • ショウレイ ガンケン フシュ オ テイシ ヒフ キンエン ト カンベツ オ ヨウシタ アミオダロン ユウハツセイ コウジョウセン キノウ テイカショウ

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Abstract

We report a 62-year-old man with puffy eyelids caused by amiodarone-induced hypothyroidism and elevated levels of serum muscle enzymes. He had been diagnosed as having spontaneous dilated cardiomyopathy in July 1990 and had received amiodarone hydrochloride (Ancaron®) since May 10, 2001. In January 2002, erythematous puffy edema appeared in the periocular regions without subjective symptoms and gradually expanded around the eyelids. Tentative clinical diagnoses included dermatomyositis or photosensitivity due to amiodarone hydrochloride. Despite the elevated levels of serum myoglobin and aldolase, histopathologic features showed no liquefactive degeneration suggestive of dermatomyositis. The eyelid lesion was weakly positive for mucin. Neither muscle weakness nor abnormal findings of electromyogram were observed. Phototests using UVA and UVB were normal. Hypothyroidism due to amiodarone hydrochloride was diagnosed because of increased levels of TSH with decreased freeT4 levels. Administration of levothyroxine sodium (Tyradin S®) improved the hypothyroidism and skin lesions.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 66 (6), 582-584, 2004

    Western Division of Japanese Dermatological Association

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