Two Cases of Dyshidrosiform Pemphigoid

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  • Ｄｙｓｈｉｄｒｏｓｉｆｏｒｍ　Ｐｅｍｐｈｉｇｏｉｄの２例

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Abstract

Case 1 was an 86-year-old Japanese male who noticed tense vesicles on his palms and soles accompanied by severe itching. Histopathology revealed subepidermal blisters with cell infiltration composed of eosinophils and lymphocytes. A linear C3 deposit at the basement membrane zone was seen by direct immunofluorescence. Indirect immunofluorescence detected anti-basement membrane zone IgG antibodies at a titer of 1 : 160. Indirect immunofluorescence using 1M NaCl split skin detected both IgG and IgA antibodies reacting with the epidermal side of the split. Immunoblotting studies showed that the IgG antibodies reacted with BP180. Case 2 was an 85-year-old Japanese male who noticed tense vesicles on his soles. New vesicles developed on his palms and trunk. Histopathology revealed subepidermal blisters with cell infiltration composed of eosinophils and lymphocytes. Linear IgG and C3 deposits at the basement membrane zone were seen by direct immunofluorescence. Indirect immunofluorescence detected anti-basement membrane zone antibodies at a titer of 1 : 160. Indirect immunofluorescence using 1M NaCl split skin detected both IgG and IgA antibodies reacting with the epidermal side of the split. Immunoblotting studies showed that IgG antibodies reacted with BP180. Both patients responded well to oral corticosteroid treatment.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 66 (5), 447-450, 2004

    Western Division of Japanese Dermatological Association

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