The Effect of Narrow-band UVB for Treatment of Generalized Vitiligo

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  • KATO Yoshihiro
    Kakuozan Dermatological Clinic
  • SHINTANI Yoichi
    Department of Geriatric and Environment Dermatology, Nagoya City University Gradeate School of Medical Sciences
  • MORITA Akimichi
    Department of Geriatric and Environment Dermatology, Nagoya City University Gradeate School of Medical Sciences

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  • 汎発型尋常性白斑に対するナローバンドUVB療法の有効性

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Abstract

Vitiligo is a refractory skin disease that is resistant to oral and topical steroid, topical vitamin D3 and PUVA therapy. In recent foreign studies, narrow-band UVB was shown to be highly effective for the treatment of vitiligo. We treated 4 patients with generalized vitiligo (mean age 51 years). The mean duration of disease was 12 years. We initiated exposure from 50% of the minimal erythema and gradually increased the dose by 10% with each exposure. Maximum exposure dose was achieved when pigmentation was found in the lesion. Average exposure rate was 10 to 39 (9.8-38.4 J/cm2). Complete repigmentation was achieved in all cases with facial lesions, and one case of a truncal lesion. For another case of truncal lesions, slight repigmentation was noted. However, there was no repigmentation in hand lesions. These results indicated that narrow-band UVB should be very effective for treatment of generalized vitiligo, especially for facial and truncal lesions.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 66 (5), 515-518, 2004

    Western Division of Japanese Dermatological Association

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