A Case of Atypical Fibroxanthoma

DOI 20 References
  • YASUMATSU Tomoko
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • TAKEUCHI Yoshiharu
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • ASADA Yuji
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • SONODA Tadashige
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • FUJIWARA Sakuhei
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University

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  • Ａｔｙｐｉｃａｌ　Ｆｉｂｒｏｘａｎｔｈｏｍａの１例

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Abstract

An 84-year-old female had complained of a painless small tumor on her right cheek for one year. The size of the tumor had gradually increased. Based on findings of biopsy, atypical fibroxanthoma was suspected, and the patient was referred to us. The tumor in her right cheek was dark reddish-brown and dome-shaped, 16 × 15 × 8 mm in size. The tumor was removed with a 3 mm margin from the tumor edge, including part of orbicular muscles. There has been no recurrence in the two years after surgery. Histologically, the tumor consisted of mainly spindle cells and partially of round pleomorphic cells with or without multinucleation and mitotic figures. Although the tumor was near the subcutaneous tissue, there was a zone of solar elastosis between the tumor and subcutis, which indicated that this tumor had arisen from the upper dermis. From the clinical and pathological features of the tumor, we diagnosed it as atypical fibroxanthoma. Several cutaneous spindle cell tumors, including spindle cell squamous cell carcinoma, dermatofibrosarcoma protuberans, desmoplastic melanoma, and leiomyosarcoma, can be differentiated using immunohistochemical staining with antibodies against cytokeratin, CD34, desmin and S100. In order to study the cellular features of this tumor, immunohistochemical staining with anti-CD68 and anti-CD74 was performed. Both antibodies reacted with tumor cells of both atypical fibroxanthoma and malignant fibrous histiocytoma and we could not find clear differences between the cells of the two tumors with these antibodies.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 66 (4), 353-356, 2004

    Western Division of Japanese Dermatological Association

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