Effects of Verapamil on PhIP-induced Tumorigenesis in F344 Rats.

• 矢田 英昭

  Department of Pathology, Nagoya City University Medical School

• 長谷川 良平

  Department of Pathology, Nagoya City University Medical School

• 広瀬 雅雄

  Department of Pathology, Nagoya City University Medical School

• 白井 智之

  Department of Pathology, Nagoya City University Medical School

• 伊東 信行

  Department of Pathology, Nagoya City University

抄録

Possible modifying effects of verapamil on 2-amino-l-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) car-cinogenicity were investigated. Male and female F344 rats were administered both PhIP, 0.02% in the diet, and verapamil, 0.05% in the diet (group 1), or either PhIP (group 2) or verapamil (group 3) alone for 52 weeks. Development of mammary tumors induced by PhIP in females was delayed by verapamil coadministration, although the final incidence of adenocar-cinomas was not statistically significant between groups l and 2. These findings were not related to the changes in body weight gain. In males, PhIP induction of intestinal tumors was not affected by verapamil coadministration. In other organs, verapamil did not change the appearance of toxic and neoplastic lesions induced by PhIP. Thus, verapamil exerted only slight inhibitory effect on mammary tumor development.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 10 (1), 45-49, 1997

  日本毒性病理学会

キーワード

• PhIP carcinogenesis
• Verapamil
• Chemoprevention
• Mammary carcinoma
• Rat

詳細情報

• CRID: 1390282679393005312
• NII論文ID: 10019087192
• NII書誌ID: AA12022786
• DOI: 10.1293/tox.10.45
• ISSN: 1881915X
• ISSN: 09149198
• Web Site: http://www.jstage.jst.go.jp/article/tox1988/10/1/10_1_45/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/1999053590
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可