癌細胞における抗アポトーシス分子TUCAN-54の役割  [in Japanese] The Roles of a Novel Anti-apoptotic Protein, TUCAN-54, in Cancer Cells  [in Japanese]

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Author(s)

Abstract

Several mechanisms have been described by which malignant cells escape from the immune system and/or chemotherapy. Recently we isolated TUCAN-54 gene that is over-expressed in a wide variety of epithelial cancers but not in normal counterparts. TUCAN-54 inhibited both death receptor-mediated and mitochondria/cytochrome <i>C</i>-mediated apoptosis. Moreover, down-regulation of TUCAN-54 in colon cancer cells by siRNA treatment could increase the sensitivity of the cells to an anti-cancer drug. Finally, we revealed that Fas-associated death domain protein (FADD) was physically associated with TUCAN-54, but not with TUCAN-48. Thus, TUCAN-54 might be a novel tumor-specific anti-apoptotic molecule, which might aggravate malignant potential of cancer cells, such as immunoresistance and chemoresistance.

Journal

  • Journal of the Mass Spectrometry Society of Japan

    Journal of the Mass Spectrometry Society of Japan 54(3), 97-101, 2006-06-01

    The Mass Spectrometry Society of Japan

References:  4

  • <no title>

    KUMAR V.

    Pathologic Basis of Disease, 2004

    Cited by (1)

  • <no title>

    YAMAMOTO M.

    Cancer Res. 65, 8706, 2005

    Cited by (1)

  • <no title>

    田沼靖一編

    アポトーシスがわかる, 2001

    Cited by (1)

  • <no title>

    PATHAN N

    J. Biol. Chem. 276, 32220, 2001

    Cited by (3)

Codes

  • NII Article ID (NAID)
    10019164397
  • NII NACSIS-CAT ID (NCID)
    AN0010555X
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    13408097
  • NDL Article ID
    7984665
  • NDL Source Classification
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL Call No.
    Z17-213
  • Data Source
    CJP  NDL  J-STAGE 
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