癌細胞における抗アポトーシス分子TUCAN-54の役割 [in Japanese] The Roles of a Novel Anti-apoptotic Protein, TUCAN-54, in Cancer Cells [in Japanese]
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Several mechanisms have been described by which malignant cells escape from the immune system and/or chemotherapy. Recently we isolated TUCAN-54 gene that is over-expressed in a wide variety of epithelial cancers but not in normal counterparts. TUCAN-54 inhibited both death receptor-mediated and mitochondria/cytochrome <i>C</i>-mediated apoptosis. Moreover, down-regulation of TUCAN-54 in colon cancer cells by siRNA treatment could increase the sensitivity of the cells to an anti-cancer drug. Finally, we revealed that Fas-associated death domain protein (FADD) was physically associated with TUCAN-54, but not with TUCAN-48. Thus, TUCAN-54 might be a novel tumor-specific anti-apoptotic molecule, which might aggravate malignant potential of cancer cells, such as immunoresistance and chemoresistance.
- Journal of the Mass Spectrometry Society of Japan
Journal of the Mass Spectrometry Society of Japan 54(3), 97-101, 2006-06-01
The Mass Spectrometry Society of Japan