Role of the LTB4/BLT1 Pathway in Allergen-induced Airway Hyperresponsiveness Inflammation
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- Miyahara Nobuaki
- Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center
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- Miyahara Satoko
- Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center
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- Takeda Katsuyuki
- Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center
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- Gelfand Erwin W
- Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center
書誌事項
- タイトル別名
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- Role of the LTB4/BLT1 Pathway in Allergen-induced Airway Hyperresponsiveness and Inflammation
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抄録
LTB4, a proinflammatory lipid mediator generated from arachidonic acid through the action of 5-lipoxygenase, has been known for over two decades and is implicated in a wide variety of inflammatory disorders. BLT1, a G-protein-coupled receptor, has recently been identified as a high affinity receptor specific for LTB4. Recent studies in allergen-induced airway hyperresponsiveness and inflammation using mice lacking BLT1 have shown crucial new roles for leukotriene B4 and BLT1 in Th2 cytokine IL-13 production from lung T cells and recruitment of antigen-specific effector CD8+ T cells, suggesting novel mechanisms for their actions. The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.<br>
収録刊行物
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- Allergology International
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Allergology International 55 (2), 91-97, 2006
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390001204632555776
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- NII論文ID
- 10019169406
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- NII書誌ID
- AA11091750
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可