Nanoimaging of single protein molecules in cells and mice

• HIGUCHI Hideo

  Tohoku University Biomedical Engineering Research Organization

• WATANABE Tomonobu

  Tohoku University Biomedical Engineering Research Organization

• TADA Hiroshi

  Surgical Oncology, Graduate School of Medicine, Tohoku University

• TAKEDA Motohiro

  Surgical Oncology, Graduate School of Medicine, Tohoku University

• OHUCHI Noriaki

  Surgical Oncology, Graduate School of Medicine, Tohoku University

Bibliographic Information

Other Title

• バイオナノイメージングとナノ医療
• 最近の展望 バイオナノイメージングとナノ医療
• サイキン ノ テンボウ バイオナノイメージング ト ナノ イリョウ

Abstract

The movement in living organisms is produced by motor proteins, for example, myosin in muscle contraction and kinesin in vesicle transport. We reviewed the mechanism of motility of individual motor molecules employing nanotechnology. A kinesin molecule was adsorbed onto a nanobead or a quantum dot, which was captured by an optical trap and brought into contact with rail proteins. The displacement of motor molecules during force generation was determined with nanometer accuracy. These nanomeasurements and fluorescence technology were applied in nanomedicine to detect the position of proteins in cultured cells and in mice.

Journal

• Oyo Buturi

  Oyo Buturi 75 (6), 694-698, 2006-06-10

  The Japan Society of Applied Physics

Keywords

• nanotechnology
• protein
• single molecules
• nanomedicine
• quantum dots

Details

• CRID: 1390845702289017856
• NII Article ID: 10019172511
• NII Book ID: AN00026679
• DOI: 10.11470/oubutsu.75.6_694
• ISSN: 21882290
• ISSN: 03698009
• NDL BIB ID: 7947203
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7947203
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed