好酸球性副鼻腔炎に対するフルチカゾン噴霧療法(倍量投与)の試み  [in Japanese] Fluticasone Propionate Aqueous Nasal Spray for the Treatment of Chronic Sinusitis with Eosinophil  [in Japanese]

Access this Article

Author(s)

    • 太田 康 OHTA Yasushi
    • 自治医科大学付属大宮医療センター耳鼻咽喉科 Otorhinolaryngology of Omiya Medical Center Jichi Medical School
    • 椿 恵樹 TSUBAKI Keiju
    • 自治医科大学付属大宮医療センター耳鼻咽喉科 Otorhinolaryngology of Omiya Medical Center Jichi Medical School
    • 児玉 梢
    • 自治医科大学付属大宮医療センター耳鼻咽喉科 Otorhinolaryngology of Omiya Medical Center Jichi Medical School

Abstract

好酸球性副鼻腔炎患者7人に対し,フルチカゾン噴霧を通常投与量の倍量(1日4回)3ヵ月間投与しその効果を検討したところ,いずれも鼻漏,鼻閉といった鼻症状は軽快し,症状の経過は良好であった.また,副鼻腔CT上も若干の軽快が認められた.一方嗅覚障害は軽快することがなく,フルチカゾン噴霧療法ではその治療に限界があると考えられた.好酸球性副鼻腔炎症例に対しては,フルチカゾン噴霧療法(倍量投与)がある程度の効果が期待できると考えられた.

Chronic sinusitis with eosinophils easily recurs after endoscopic sinus surgery. The condition is usually complicated by asthma, and many eosinophils are present in the sinus mucosa. One conservative treatment method is the administration of glucocorticoids locally or systematically. To evaluate the efficacy and tolerability of intranasal fluticasone propionate for the treatment of chronic sinusitis with eosinophils, seven patients with chronic sinusitis with eosinophils were treated over a 12-week period using a fluticasone propionate aqueous nasal spray (800μg per day in each nostrilz). The Symptons of 7 patients, especially nasal discharge and nasal obstructions, improved and an expanded air space was observed on paranasal CT images. The percent of drug systemically available after intranasal administration varied by less than 1% for intranasal fluticasone propionate. Therefore, even if intranasal fluticasone propionate is administerved at double the usual dose, it is unlikely to cause systemic side effects. Fluticasone propionate aqueous nasal spray at double the usual dose is effective for the treatment of chronic sinusitis with eosinophils.

Journal

  • Nippon Jibiinkoka Gakkai Kaiho

    Nippon Jibiinkoka Gakkai Kaiho 109(3), 157-162, 2006-03-20

    The Oto-Rhino-Laryngological Society of Japan, Inc.

References:  22

Cited by:  3

Codes

  • NII Article ID (NAID)
    10019255375
  • NII NACSIS-CAT ID (NCID)
    AN00191551
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00306622
  • NDL Article ID
    7900506
  • NDL Source Classification
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL Call No.
    Z19-250
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
Page Top