気管支喘息患者における温泉療法とエゴマ油食の血清ECP値に対する影響 The Effect of Spa Therapy Combined with Dietary Supplementation with n-3 Fatty Acids on Serum Eosinophil Cationic Protein in Asthmatic Subjects

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Author(s)

    • 高田 真吾 TAKATA Shingo
    • 岡山大学医学部・歯学部附属病院三朝医療センター内科 Division of Medicine, Misasa Medical Center, Okayama University Medical and Dental School
    • 芦田 耕三 ASHIDA Kozo
    • 岡山大学医学部・歯学部附属病院三朝医療センター内科 Division of Medicine, Misasa Medical Center, Okayama University Medical and Dental School
    • 保崎 泰弘 [他] HOSAKI Yasuhiro
    • 岡山大学医学部・歯学部附属病院三朝医療センター内科 Division of Medicine, Misasa Medical Center, Okayama University Medical and Dental School
    • 濱田 全紀 HAMADA Masanori
    • 岡山大学医学部・歯学部附属病院三朝医療センターリハビリテーション科 Division of Rehabilitation, Misasa Medical Center, Okayama University Medical and Dental School
    • 岩垣 尚史 IWAGAKI Naofumi
    • 岡山大学医学部・歯学部附属病院三朝医療センター内科 Division of Medicine, Misasa Medical Center, Okayama University Medical and Dental School
    • 藤井 誠 FUJII Makoto
    • 岡山大学医学部・歯学部附属病院三朝医療センター内科 Division of Medicine, Misasa Medical Center, Okayama University Medical and Dental School
    • 光延 文裕 MITSUNOBU Fumihiro
    • 岡山大学医学部・歯学部附属病院三朝医療センター内科 Division of Medicine, Misasa Medical Center, Okayama University Medical and Dental School

Abstract

我々は、気管支喘息の治療に温泉療法とn-3系多価不飽和脂肪酸を多く含むエゴマ油食の併用が有効であることを報告してきた。その作用機序としては、白血球からのロイコトリエンC4 (LTC4) 産生能の抑制が示唆されたが、その解明は不十分である。そこで、今回我々は、温泉療法とエゴマ油食の気管支喘息の病態に対する作用機序を明らかにすることを目的として喘息患者の血清 eosinophil cationic protein (ECP) 値に対する併用療法の効果を検討した。症状の安定した10名の喘息患者に温泉療法及びエゴマ油食の摂取を4週間行い、その間の末梢血白血球LTC4産生能、血清ECP値、呼吸機能の変化を比較検討した。その結果、白血球LTC4産生能、血清ECP値は治療開始4週後有意に抑制された (P<0.05)。また、呼吸機能の中では、努力肺活量 (FVC) が治療開始4週後に有意に改善した (P<0.05)。4週間で血中好酸球数は低下傾向が見られたが有意の変化ではなかった。これらの結果より、温泉療法とエゴマ油食は白血球LTC4産生能、血清ECP値を抑制することにより呼吸機能を改善させ、気管支喘息の治療に有効であることが示唆された。

Recently, we have also reported that spa therapy combined with dietary supplementation of perilla seed oil would be effective for patients, and would suppress the generation of leukotriene C4 (LTC4) by peripheral leucocytes. However, it is still unclear how the combination spa therapy and dietary supplementation of perilla seed oil influences on the pathophysiology of bronchial asthma. In the present study, the effects of spa therapy combined with dietary supplementation of perilla seed oil were examined in patients with asthma in relation to the serum eosinophil cationic protein (ECP) levels to investigate the effect on bronchial asthma. Ten adult asthmatic patients with moderate type asthma in terms of severity were taken to have a complex spa therapy and consume perilla seed oil-rich diet for 4 weeks. The generation of LTC4 by peripheral leucocytes, serum ECP level and pulmonary function were measured. Significant decreases were observed for LTC4 and ECP for 4 weeks. Forced vital capacity (FVC), which was one of the pulmonary function tests, improved significantly at 4 weeks (p<0.05). The number of eosinophils decreased for 4 weeks, but the differences were not significant. The results obtained here suggest that spa therapy combined with dietary supplementation of perilla seed oil leads to decrease in LTC4 and ECP and improves pulmonary function and asthma control.

Journal

  • The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine

    The Journal of The Japanese Society of Balneology, Climatology and Physical Medicine 69(4), 261-268, 2006-08-01

    The Japanese Society of Balneology, Climatology and Physical Medicine

References:  33

Codes

  • NII Article ID (NAID)
    10019280420
  • NII NACSIS-CAT ID (NCID)
    AN00186245
  • Text Lang
    ENG
  • Article Type
    ART
  • ISSN
    00290343
  • NDL Article ID
    8079065
  • NDL Source Classification
    ZS47(科学技術--医学--治療医学・看護学・漢方医学)
  • NDL Call No.
    Z19-225
  • DOI
    10.11390/onki1962.69.261
  • Data Source
    CJP  NDL  J-STAGE 
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