書誌事項
- タイトル別名
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- Structural Study of Ferredoxin-Dependent Bilin Reductase
- サイキン ノ ケンキュウ カラ フェレドキシン イゾンセイ ビリン カンゲン コウソ ノ コウゾウ ケンキュウ
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抄録
Phytobilins, linear tetrapyrrole pigments utilized for light-harvesting and light-sensing in photosynthetic organisms, are synthesized from biliverdin by ferredoxin-dependent bilin reductases (FDBRs) . We have determined the crystal structures of substrate-free and substrate-bound forms of PcyA, one such FDBR. These structures revealed the first tertiary structures of an FDBR family member. Based on these structures, we discuss the binding mechanisms of ferredoxin and substrate to PcyA. Moreover, we propose the reaction mechanism how PcyA controls the two-step reductions of biliverdin. Homology modeling of other FDBRs using PcyA structure may provide structural bases for the reaction mechanisms of other FDBRs.
収録刊行物
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- 日本結晶学会誌
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日本結晶学会誌 48 (4), 283-289, 2006
日本結晶学会
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詳細情報 詳細情報について
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- CRID
- 1390001204086548992
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- NII論文ID
- 10019293665
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- NII書誌ID
- AN00188364
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- ISSN
- 18845576
- 03694585
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- NDL書誌ID
- 8084498
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可