2型糖尿病モデルマウスKK-A^yにおけるエトキシピコリン酸亜鉛(II)錯体の血糖上昇抑制作用 [in Japanese] Normalizing Effect of Zinc (II) Complex with 6-Ethoxy Picolinic Acid on Blood Glucose Levels in KK-A^y Mice [in Japanese]
Access this Article
Search this Article
We examined normalizing effect for blood glucose levels of zinc(II) complex with 6-ethoxy picolinic acid (Zn(6-EtOpa)<SUB>2</SUB>) on KK-A<SUP>y</SUP> mice which used in this study as the model animals of type 2 diabetes, and compared with its ligand, 6-ethoxy picolinic acid (6-EtOpa). These mice were divided into three groups after the onset of diabetes at 8 weeks of age, which were an untreated group, a 6-EtOpa treated group, and a Zn(6-EtOpa)<SUB>2</SUB> treated group. They were given daily intraperitoneal (i.p.) injections of each material for a period of 2 weeks from 8th to 10th week of ages. The dose of Zn(6-EtOpa)<SUB>2</SUB> was 3 mg Zn/kg of body weight. Each animal was examined for its body weight, food intake, blood glucose level, glucose tolerance, HbA<SUB>1c</SUB> level, hematological status, organ weight, and zinc and copper concentrations in the organs. After 2 weeks of administration, the blood glucose level of KK-A<SUP>y</SUP> mice treated with Zn(6-EtOpa)<SUB>2</SUB> showed a significant decrease compared to both of the 6-EtOpa and control groups. Furthermore, the mice treated with Zn(6-EtOpa)<SUB>2</SUB> showed decreasing effect on HbA<SUB>1c</SUB> levels and increasing effect on glucose tolerance. Zinc (II) concentration in the femur was significantly increased in the Zn(6-EtOpa)<SUB>2</SUB> treated group compared to the both of 6-EtOpa and control groups. Copper concentration was decreased significantly in both of femur and femoris muscle.
- Biomedical Research on Trace Elements
Biomedical Research on Trace Elements 17(3), 342-345, 2006-10-01
Japan Society for Biomedical Research on Trace Elements