2型糖尿病モデルマウスKK-A^yにおけるエトキシピコリン酸亜鉛(II)錯体の血糖上昇抑制作用  [in Japanese] Normalizing Effect of Zinc (II) Complex with 6-Ethoxy Picolinic Acid on Blood Glucose Levels in KK-A^y Mice  [in Japanese]

Access this Article

Author(s)

    • 森下 美香 MORISHITA Mika
    • 神戸女子大学栄養生理学研究室 Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
    • 西出 緑 NISHIDE Midori
    • 神戸女子大学栄養生理学研究室 Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University
    • 安達 祐介 ADACHI Yusuke
    • 京都薬科大学代謝分析学教室 Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
    • 吉川 豊 YOSHIKAWA Yutaka
    • 京都薬科大学代謝分析学教室 Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
    • 桜井 弘 SAKURAI Hiromu
    • 京都薬科大学代謝分析学教室 Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University
    • 梶原 苗美 KAJIWARA Naemi M.
    • 神戸女子大学栄養生理学研究室 Laboratory of Nutrition Physiology, Graduate School of Life Science, Kobe Women's University

Abstract

We examined normalizing effect for blood glucose levels of zinc(II) complex with 6-ethoxy picolinic acid (Zn(6-EtOpa)<SUB>2</SUB>) on KK-A<SUP>y</SUP> mice which used in this study as the model animals of type 2 diabetes, and compared with its ligand, 6-ethoxy picolinic acid (6-EtOpa). These mice were divided into three groups after the onset of diabetes at 8 weeks of age, which were an untreated group, a 6-EtOpa treated group, and a Zn(6-EtOpa)<SUB>2</SUB> treated group. They were given daily intraperitoneal (i.p.) injections of each material for a period of 2 weeks from 8th to 10th week of ages. The dose of Zn(6-EtOpa)<SUB>2</SUB> was 3 mg Zn/kg of body weight. Each animal was examined for its body weight, food intake, blood glucose level, glucose tolerance, HbA<SUB>1c</SUB> level, hematological status, organ weight, and zinc and copper concentrations in the organs. After 2 weeks of administration, the blood glucose level of KK-A<SUP>y</SUP> mice treated with Zn(6-EtOpa)<SUB>2</SUB> showed a significant decrease compared to both of the 6-EtOpa and control groups. Furthermore, the mice treated with Zn(6-EtOpa)<SUB>2</SUB> showed decreasing effect on HbA<SUB>1c</SUB> levels and increasing effect on glucose tolerance. Zinc (II) concentration in the femur was significantly increased in the Zn(6-EtOpa)<SUB>2</SUB> treated group compared to the both of 6-EtOpa and control groups. Copper concentration was decreased significantly in both of femur and femoris muscle.

Journal

  • Biomedical Research on Trace Elements

    Biomedical Research on Trace Elements 17(3), 342-345, 2006-10-01

    Japan Society for Biomedical Research on Trace Elements

References:  15

Codes

  • NII Article ID (NAID)
    10019372677
  • NII NACSIS-CAT ID (NCID)
    AN10423256
  • Text Lang
    JPN
  • Article Type
    SHO
  • ISSN
    0916717X
  • NDL Article ID
    8576097
  • NDL Source Classification
    ZS8(科学技術--医学--解剖学・生理学・生化学)
  • NDL Call No.
    Z19-3255
  • Data Source
    CJP  NDL  J-STAGE 
Page Top