Baroreflex Increases Correlation and Coherence of Muscle Sympathetic Nerve Activity (SNA) with Renal and Cardiac SNAs
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- Kamiya Atsunori
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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- Kawada Toru
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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- Mizuno Masaki
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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- Miyamoto Tadayoshi
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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- Uemura Kazunori
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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- Seki Kenjiro
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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- Shimizu Shuji
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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- Sugimachi Masaru
- Department of Cardiovascular Dynamics, National Cardiovascular Centre Research Institute
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Abstract
Despite accumulating data of muscle sympathetic nerve activity (SNA) measured by human microneurography, whether neural discharges of muscle SNA correlates and coheres with those of other SNAs controlling visceral organs remains unclear. Further, how the baroreflex control of SNA affects the relations between these SNAs remains unknown. In urethane and α-chloralose anesthetized, vagotomized, and aortic-denervated rabbits, we recorded muscle SNA from the tibial nerve using microneurography and simultaneously recorded renal and cardiac SNAs. After isolating the carotid sinuses, we produced a baroreflex closed-loop condition by matching the isolated intracarotid sinus pressure (CSP) with systemic arterial pressure (CLOSE). We also fixed CSP at operating pressure (FIX) or altered CSP widely (WIDE: operating pressure ± 40 mmHg). Under these conditions, we calculated time-domain and frequency-domain measures of the correlation between muscle SNA and renal or cardiac SNAs. At CLOSE, muscle SNA resampled at 1 Hz correlated with both renal (r2 = 0.71 ± 0.04, delay = 0.10 ± 0.004 s) and cardiac SNAs (r2 = 0.58 ± 0.03, delay = 0.13 ± 0.004 s) at optimal delays. Moreover,muscle SNA at CLOSE strongly cohered with renal and cardiac SNAs(coherence >0.8) at the autospectral peak frequencies, and weakly (0.4–0.5) at the remaining frequencies. Increasing the magnitude of CSP change from FIX to CLOSE and further to WIDE resulted in corresponding increases in correlation and coherence functions at nonpeak frequencies, and the coherence functions at peak frequencies remained high (>0.8). In conclusion, muscle SNA correlates and coheres approximately with renal and cardiac SNAs under closed-loop baroreflex conditions. The arterial baroreflex is capable of potently homogenizing neural discharges of these SNAs by modulating SNA at the nonpeak frequencies of SNA autospectra.<br>
Journal
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- The Journal of Physiological Sciences
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The Journal of Physiological Sciences 56 (5), 325-333, 2006
PHYSIOLOGICAL SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390001205250247680
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- NII Article ID
- 10019380010
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- NII Book ID
- AA12129145
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- ISSN
- 18806562
- 18806546
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- NDL BIB ID
- 8525782
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed