Induction system of neuronal and muscle cells from bone marrow stromal cells and applications for degenerative diseases

• Dezawa Mari

  Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine

Abstract

Bone marrow stromal cells (MSCs) have great potential as therapeutic agents since they are easily isolated and can be expanded from patients without serious ethical or technical problems. Recently, new methods for the highly efficient and specific induction of functional neuronal cells and skeletal muscle cells have been found in MSCs. These induced cells were transplanted into animal models of spinal cord injury, stroke, Parkinson's disease and muscle degeneration, resulting in the successful integration of transplanted cells and improvement in the behavior of the transplanted animals. Here I describe the discovery of these induction systems and focus on the potential use of MSC-derived cells for neuro- and muscle-degenerative diseases.

Journal

• Inflammation and Regeneration

  Inflammation and Regeneration 27 (2), 96-101, 2007

  The Japanese Society of Inflammation and Regeneration

Keywords

• mesenchymal stem cells
• transdifferentiation
• regenerative medicine
• cell therapy
• transplantation

Details

• CRID: 1390001205256710912
• NII Article ID: 10019482504
• NII Book ID: AA11508953
• DOI: 10.2492/inflammregen.27.96
• ISSN: 18808190
• ISSN: 18809693
• NDL BIB ID: 8778629
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8778629
• Web Site: https://search.jamas.or.jp/link/ui/2007265404
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed