Anti-inflammatory Effects of Simvastatin on Human Oral Cells

• Sakoda Kenji

  Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences

• Yamamoto Matsuo

  Department of Periodontology, School of Dentistry, Showa University

• Negishi Yoichi

  School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

• Liao James K

  Vascular Medicine Unit, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, U.S.A.

• Node Koichi

  Department of Cardiovascular & Renal Medicine, Saga University Faculty of Medicine

• Izumi Yuichi

  Department of Periodontology, Kagoshima University Graduate School of Medical and Dental Sciences

抄録

Periodontitis is a chronic inflammatory disease associated with degradation of periodontal tissues and is highly prevalent in late middle age.<BR>Statins, such as simvastatin, are pharmacologic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors that inhibit cholesterol synthesis, which is important in development of arteriosclerosis. Many cardiovascular studies have suggested that statins also have anti-inflammatory effects which are independent of cholesterol lowering. As a chronic inflammatory disease, periodontitis shares some mechanisms with atherosclerosis. Since oral epithelial cells are implicated in periodontal inflammation, we measured simvastatin effects on cytokine [interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12p70, and tumor necrosis factor α (TNFα)] production by cultured human epithelioid cell line KB cells in response to IL-1α. Simvastatin decreased production, an effect reversed by adding mevalonate or geranylgeranyl pyrophosphate (GGPP), but not farnesyl pyrophosphate (FPP). Simvastatin was found to reduce NF-κB and AP-1 promoter activity in KB cells. Our results support an anti-inflammatory effect of simvastatin on human oral epithelial cells.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 27 (2), 107-111, 2007

  一般社団法人 日本炎症・再生医学会

キーワード

• simvastatin (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor)
• pleiotropic effects
• inflammatory cytokines
• periodontitis

詳細情報

• CRID: 1390001205256734848
• NII論文ID: 10019482557
• NII書誌ID: AA11508953
• DOI: 10.2492/inflammregen.27.107
• COI: 1:CAS:528:DC%2BD2sXlslWnurs%3D
• ISSN: 18808190
• ISSN: 18809693
• NDL書誌ID: 8778669
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8778669
• Web Site: https://search.jamas.or.jp/link/ui/2007265406
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可