Increased Level of Serum Vascular Endothelial Growth Factor by Long-Term Exposure to Hypergravity

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  • OSHIMA Masanobu
    Division of Genetics, Cancer Research Institute, Kanazawa University
  • SUZUKI Hiromi
    Japan Space Forum
  • GUO Xiaoying
    Division of Genetics, Cancer Research Institute, Kanazawa University School of Public Health, China Medical University
  • OSHIMA Hiroko
    Division of Genetics, Cancer Research Institute, Kanazawa University

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Abstract

We have previously demonstrated that short-term exposure to hypergravity at 2G for 4 h induces expression of cyclooxygenase-2 (COX-2) in the mouse heart. Moreover, expression of vascular endothelial growth factor (VEGF) is also induced in the heart in a COX-2-dependent manner. Here, we demonstrate that long-term exposure of mice to 2G for 24 h resulted in a significant increase of serum VEGF level, although expression of COX-2 and VEGF in the heart decreased to the 1G-control level. Moreover, increase of serum VEGF was not suppressed by treatment with COX-2 inhibitor, indicating that VEGF was induced in a COX-2-independent manner. These results suggest that gravitational force contributes to maintenance of the serum VEGF level.<br>

Journal

  • Experimental Animals

    Experimental Animals 56 (4), 309-313, 2007

    Japanese Association for Laboratory Animal Science

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