What is the Critical Hyperthermia Target in Cancer Cells?

• TAKAHASHI AKIHISA

  Department of Biology, Nara Medical University School of Medicine

• OHNISHI TAKEO

  Department of Biology, Nara Medical University School of Medicine

Bibliographic Information

Other Title

• ハイパーサーミアのターゲットは何か?

Abstract

Currently, the molecular mechanisms involved in heat-induced cell killing are not completely understood, although protein denaturation is known to be the major target for hyperthermia in cancer cells. A new hypothesis is described here which proposes that heat-induced cell killing is associated with cellular DNA double-strand break (DSB) formation. This review provides details of this model for hyperthermia cell killing, and a possible mechanism to explain heat-induced DSB formation.

Journal

• Thermal Medicine(Japanese Journal of Hyperthermic Oncology)

  Thermal Medicine(Japanese Journal of Hyperthermic Oncology) 22 (4), 229-237, 2006

  Japanese Society for Thermal Medicine

Keywords

• hyperthermia
• cell killing
• protein denaturation
• γH2AX
• double-strand break

Details

• CRID: 1390001204350956160
• NII Article ID: 130004510267
• NII Article ID: 120004973449
• NII Article ID: 10019596974
• NII Book ID: AN10084762
• DOI: 10.3191/thermalmedicine.22.229
• ISSN: 18819516
• ISSN: 09112529
• Web Site: http://hdl.handle.net/10564/908
• Web Site: https://search.jamas.or.jp/link/ui/2007098924
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed