Brain Metastases after Achieving Local Pathological Complete Responses with Neoadjuvant Chemotherapy
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- Tsukamoto Shunsuke
- Breast Surgery Division, National Cancer Center hospital.
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- Akashi-Tanaka Sadako
- Breast Surgery Division, National Cancer Center hospital.
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- Shien Tadahiko
- Breast Surgery Division, National Cancer Center hospital.
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- Terada Kotoe
- Breast Surgery Division, National Cancer Center hospital.
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- Kinoshita Takayuki
- Breast Surgery Division, National Cancer Center hospital.
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Background: We encountered two patients with inflammatory breast carcinoma who developed symptomatic brain metastases after achieving local pathological complete responses (pCR) with neoadjuvant chemotherapy (NAC).<BR>Case presentations: The first patient is a 39-year-old woman (Case 1), who underwent NAC with AC (doxorubicin + cyclophosphamide)followed by weekly paclitaxel. After achieving a clinical CR (cCR), we conducted a modified radical mastectomy. Pathological evaluation confirmed no residual malignant cells within the breast tissue or lymph nodes. However, she developed neurological symptoms from brain metastases one month postoperatively. The second patient is a 44-year-old woman (Case 2). Again, no residual malignant cells were detected within the breast tissue or lymph nodes following NAC, but the patient developed symptomatic brain metastases eight months postoperatively. When primary breast tumors are locally advanced, it may be worthwhile to rule out brain metastases even if pCR is obtained after NAC.
収録刊行物
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- Breast Cancer
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Breast Cancer 14 (4), 420-424, 2007
日本乳癌学会
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詳細情報 詳細情報について
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- CRID
- 1390282679457560704
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- NII論文ID
- 10019800660
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- NII書誌ID
- AA1103354X
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- ISSN
- 18804233
- 13406868
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可