UGT2B7^*3はR-, S-カルベジロールの体内動態に影響を及ぼさない UGT2B7^*3 did not Affect the Pharmacokinetics of R- and S-Carvedilol in Healthy Japanese

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Author(s)

    • HONDA Mutsuko
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • TOYODA Wakako
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • SHIMIZU Takako
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • HORIUCHI Isao
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • KAYANO Yuichiro
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • TAGUCHI Masato
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • NOZAWA Takashi
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • INOUE Hiroshi
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
    • HASHIMOTO Yukiya
    • Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Abstract

  We previously investigated the pharmacokinetics of <i>R</i>- and <i>S</i>-carvedilol in 54 healthy Japanese subjects, and reported that the oral clearance (<i>CL/F</i>) and apparent volume of distribution (<i>V/F</i>) of both enantiomers in subjects with the <i>CYP2D6<sup>*</sup>10</i> allele were significantly lower than those in subjects without the <i>CYP2D6<sup>*</sup>10</i> allele. In the present study, we examined the genotype of <i>UGT2B7</i> in these 54 subjects, and investigated the effect of <i>UGT2B7<sup>*</sup>3</i> on the pharmacokinetics of <i>R</i>- and <i>S</i>-carvedilol. Forty-three subjects did not have the <i>UGT2B7<sup>*</sup>3</i> allele, and 11 subjects had one <i>UGT2B7<sup>*</sup>3</i> allele. <i>CL/F</i> and <i>V/F</i> values of <i>R</i>- and <i>S</i>-carvedilol in the subjects with one <i>UGT2B7<sup>*</sup>3</i> allele were similar to those without the <i>UGT2B7<sup>*</sup>3</i> allele, indicating that the <i>UGT2B7<sup>*</sup>3</i> allele did not significantly affect the systemic clearance (<i>CL</i>) and bioavailability (<i>F</i>) of the two enantiomers.<br>

Journal

  • Drug Metabolism and Pharmacokinetics

    Drug Metabolism and Pharmacokinetics 22(5), 382-386, 2007-10-25

    The Japanese Society for the Study of Xenobiotics

References:  7

Cited by:  2

Codes

  • NII Article ID (NAID)
    10019806805
  • NII NACSIS-CAT ID (NCID)
    AA1162652X
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13474367
  • Data Source
    CJP  CJPref  J-STAGE 
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