重イオンマイクロビームを用いた細胞1個の狙い撃ち照射  [in Japanese] Single-cell/Single-particle Irradiation Using Heavy-ion Microbeams  [in Japanese]

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Author(s)

    • 小林 泰彦 KOBAYASHI Yasuhiko
    • (独)日本原子力研究開発機構 量子ビーム応用研究部門 バイオ応用技術研究ユニット マイクロビーム細胞照射研究グループ Microbeam Radiation Biology Group, Radiation-Applied Biology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency (JAEA)

Abstract

  Heavy charged particles transfer their energy to biological organisms through high-density ionization along the particle trajectories. The population of cells exposed to a very low dose of heavy-ion beams contains a few cells hit by a particle, while the majority of the cells receive no radiation damage. At somewhat higher doses, some of the cells receive two or more events according to the Poisson distribution of ion injections. This fluctuation of particle trajectories through individual cells makes interpretation of radiological effects of heavy ions difficult. Furthermore, there has recently been an increasing interest in ionizing radiation-induced “bystander effects”, that is, radiation effects transmitted from hit cells to neighboring un-hit cells. Therefore, we have established a single-cell/single-particle irradiation system using a heavy-ion microbeam apparatus at JAEA-Takasaki to study radiobiological processes in hit cells and bystander cells exposed to low dose and low dose-rate high-LET radiations, in ways that cannot be achieved using conventional broad-field exposures.<br>

Journal

  • Shinku

    Shinku 50(9), 564-568, 2007-09-20

    The Vacuum Society of Japan

References:  39

Codes

  • NII Article ID (NAID)
    10019835868
  • NII NACSIS-CAT ID (NCID)
    AN00119871
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    05598516
  • NDL Article ID
    8976189
  • NDL Source Classification
    ZN15(科学技術--機械工学・工業--流体機械)
  • NDL Call No.
    Z16-474
  • Data Source
    CJP  NDL  J-STAGE 
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