Role of Vitamin A in Gut Mucosal Immunity
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- Iwata Makoto
- Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University
Bibliographic Information
- Other Title
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- 腸管免疫におけるビタミンAの役割
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Abstract
The deployment of immune cells is essential in the gut since it has a wide surface area directly facing to the outer world. In general, there are certain rules for lymphocytes to be deployed into tissues. Nave T cells can immigrate into the secondary lymphoid organs, but cannot immigrate into non-lymphoid tissues. However, once they are activated in a secondary lymphoid organ and become effector/memory T cells, they can selectively immigrate into the tissue associated with the secondary lymphoid organ where they were activated. For example, T cells activated in the gut-associated lymphoid organs, Peyer's patches and mesenteric lymph nodes, express the gut-homing receptors, integrin α4β7 and chemokine receptor CCR9, and become capable of immigrating into the small intestinal tissues. We found that dendritic cells in gut-associated lymphoid organs imprint gut-homing specificity on T cells by producing retinoic acid from vitamin A and giving it to T cells during antigen presentation. Furthermore, retinoic acid also plays a critical role in imprinting B cells with gut-homing specificity and inducing their differentiation to IgA-producing cells.<br>
Journal
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- Journal of Intestinal Microbiology
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Journal of Intestinal Microbiology 21 (4), 297-304, 2007
The Intestinal Microbiology Society
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Keywords
Details 詳細情報について
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- CRID
- 1390282679328003712
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- NII Article ID
- 10019966283
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- NII Book ID
- AA11373504
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- ISSN
- 13498363
- 13430882
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed