Concept of and countermeasures against metabolic syndrome

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  • SHIWAKU Kuninori
    Dept. of Environmental and Preventive Medicine, Shimane University School of Medicine
  • YAMASAKI Masayuki
    Dept. of Environmental and Preventive Medicine, Shimane University School of Medicine
  • IWAMOTO Mamiko
    Dept. of Environmental and Preventive Medicine, Shimane University School of Medicine
  • IKENISHI Rumi
    Dept. of Environmental and Preventive Medicine, Shimane University School of Medicine
  • YONEYAMA Toshimi
    Dept. of Environmental and Preventive Medicine, Shimane University School of Medicine
  • LI Limei
    Dept. of Environmental and Preventive Medicine, Shimane University School of Medicine College of Traditional Chinese Medicine, Ningxia Medical College
  • WANG Li
    Dept. of Environmental and Preventive Medicine, Shimane University School of Medicine
  • NOGI Akiko
    Dept. of Human Nutrition, Faculty of Nursing and Human Nutrition, Yamaguchi Prefectural University

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  • メタボリックシンドロームの疾病概念とその対策
  • メタボリックシンドローム ノ シッペイ ガイネン ト ソノ タイサク

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Abstract

  A cluster of certain metabolic abnormalities has been recognized as metabolic syndrome, which is characterized by resistance to insulin-stimulated glucose uptake, glucose intolerance, hyperinsulinemia, hypertriglyceridemia, hypo- HDL cholesterolemia (HDL-C) and hypertension, with or without hyperglycemia. These multiple metabolic disorders put a person at high risk for cardiovascular disease. With the goal to eliminate all adverse consequences of multiple metabolic disorders, the optimal approach would be through its prevention. Since visceral obesity has been proposed as the most important determinant of multiple metabolic disorders by the International Diabetes Federation and the Japanese Association of Internal Medicine in 2005, health practitioners were thrown into confusion to use any definitions of metabolic syndrome. The Japanese Ministry of Health, Labor and Welfare has decided to introduce a new policy for the prevention of metabolic syndrome and type 2 diabetes mellitus from April 2008. The Ministry of Health, Labor and Welfare conducts to establish a screening system and guidance of the metabolic syndrome. We review the history and concept of metabolic syndrome, insulin resistance and central obesity, pathophysiology and definition, and countermeasures against the metabolic syndrome, to improve the community health care system for the metabolic syndrome and cardiovascular disease.

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