Effect of Tacrolimus in a Case of Autoimmune Encephalitis

DOI PubMed 1 Citations 15 References
  • Hirano Keiko
    Department of Pediatric Neurology, Shizuoka Children's Hospital
  • Aiba Hideo
    Department of Pediatric Neurology, Shizuoka Children's Hospital
  • Yano Masayuki
    Department of Pediatric Radiology, Shizuoka Children's Hospital
  • Watanabe Seiji
    Department of Pediatric Neurology, Shizuoka Children's Hospital
  • Okumura Yoshinori
    Department of Pediatric Neurology, Shizuoka Children's Hospital
  • Takahashi Yukitoshi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders

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Other Title
  • Ｔａｃｒｏｌｉｍｕｓが奏効した自己免疫性脳炎の１例

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Abstract

We report a 17-year-old boy who was diagnosed as autoimmune encephalitis with various neurological complications such as hemiplegia, aphasia and seizures. An autoimmune process was considered to be responsible for the repeated episodes of encephalitis because the symptoms were highly responsive to steroids and anti-glutamate receptor antibodies were detected in the CSF. After administration of the immunosuppressant tacrolimus, we could taper the steroid dosage. He has had no relapse for three years to date. We demonstrated the possibility of steroid-sparing treatment with tacrolimus for a patient with steroid-responsive encephalitis. There were few reports describing tacrolimus therapy for encephalitis. Tacrolimus may be effective for selected patients with recurrent encephalitis in which an autoimmune mechanism is considered as the pathogenesis.

Journal

  • NO TO HATATSU

    NO TO HATATSU 39 (6), 436-439, 2007

    THE JAPANESE SOCIETY OF CHILD NEUROLOGY

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