ブレベトキシンＢの全合成

• 門田 功

  岡山大学大学院自然科学研究科分子科学専攻

• 高村 浩由

  名古屋大学大学院理学研究科

書誌事項

タイトル別名

• Total Synthesis of Brevetoxin B
• ブレベトキシン B ノ ゼンゴウセイ

抄録

Brevetoxin B was isolated from the red tide organism Karenia brevis in 1981 as the first example of marine polycyclic ethers. This compound shows potent neurotoxicity, by binding to sodium channels, causing massive fish kills and human health problems. Since further biological studies are hampered by the limited availability from nature, chemical synthesis has been the sole realistic way to obtain sufficient amounts of brevetoxin B. Moreover, the huge molecular architecture is a particularly attractive target for synthetic chemists. In this account, we describe the highly convergent total synthesis of brevetoxin B based on our methodology, including intramolecular allylation and subsequent ring-closing metathesis.

収録刊行物

• 有機合成化学協会誌

  有機合成化学協会誌 65 (5), 430-438, 2007

  公益社団法人 有機合成化学協会

キーワード

• brevetoxin B
• polycyclic ethers
• total synthesis
• intramolecular allylation
• ring-closing metathesis

詳細情報

• CRID: 1390001205312598400
• NII論文ID: 10020137685
• NII書誌ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.65.430
• ISSN: 18836526
• ISSN: 00379980
• NDL書誌ID: 8817772
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8817772
• 本文言語コード: ja
• データソース種別:
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  • NDL
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可