生物活性分子の触媒的不斉合成

DOI Web Site 被引用文献1件 参考文献39件

書誌事項

タイトル別名
  • Catalytic Asymmetric Synthesis of Biologically Active Molecules
  • セイブツ カッセイ ブンシ ノ ショクバイテキ フセイ ゴウセイ

この論文をさがす

抄録

Based on the concept of bifunctional asymmetric catalysis, chiral ligands containing a carbohydrate scaffold were designed. Rare earth metal complexes of the ligands produced general and practical catalytic enantioselective cyanation of ketones and ketoimines. Structural studies of the asymmetric catalysts revealed that the active catalysts are polymetallic complexes containing higher-order structures. The higher-order structure determines the function (activity and enantioselectivity) of the catalysts. The thus-developed catalytic enantioselective methods for the synthesis of tetrasubstituted carbons were applied to the synthesis of biologically active molecules. Catalytic asymmetric synthesis of fostriecin and its analog, lactacystin, Tamiflu®, and garsubellin A are described.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (39)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ