Volatile Anesthetic Vascular Pharmacology: Changes in Vascular Responsiveness to Volatile Anesthetics Associated with Aging, Hypertension, and Diabetes Mellitus in Systemic Resistance Arteries

• AKATA Takashi

  Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Kyusyu University Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

• IZUMI Kaoru

  Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

• YOSHINO Jun

  Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

• SHIROZU Kazuhiro

  Department of Anesthesiology and Critical Care Medicine, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title

• 抵抗血管におけるノルアドレナリン収縮反応に及ぼす揮発性麻酔薬の影響―加齢，高血圧，糖尿病に伴う変化に注目して―

Abstract

  Volatile anesthetics cause hemodynamic instability and significantly alter blood flow to various organs. The overall impact is systemic hypotension, which is attributable to myocardial depression, peripheral vasodilation, and attenuated sympathetic nervous system activity. However, one of these factors could be more causative than the others, depending on the anesthetic agent and cardiovascular factors inherent in patients. It is well recognized that patients with impaired cardiovascular function such as elderly patients or patients with heart diseases, atherosclerosis, hypertension, or diabetes mellitus are at increased risk for the hemodynamic instability caused by volatile anesthetics. Noradrenaline plays a central role in the sympathetic maintenance of systemic vascular resistance and thus of perfusion pressure to the vital organs (e. g. , the brain, heart) . In this article, we review the direct (i. e. , non-neural) actions of volatile anesthetics on the contractile response to noradrenaline in systemic resistance arteries, focusing on the influence of the endothelium. We also introduce our recent observations on the changes in vascular responsiveness to volatile anesthetics associated with aging, non-treated hypertension, and non-treated diabetes mellitus.

Journal

• THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA

  THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 27 (3), 207-217, 2007

  THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA

Keywords

• Volatile anesthetic
• Vascular smooth muscle
• Systemic resistance artery

Details

• CRID: 1390282679735747072
• NII Article ID: 10020161456
• NII Article ID: 130004449645
• NII Book ID: AN00330159
• DOI: 10.2199/jjsca.27.207
• ISSN: 13499149
• ISSN: 02854945
• Web Site: https://search.jamas.or.jp/link/ui/2007270938
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed