Inactivation of Microorganisms and Endotoxins by Low Temperature Nitrogen Gas Plasma Exposure

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Abstract

The plasma of several different gases has shown a sporicidal activity. From these gases, nitrogen gas was most difficult to produce atomic nitrogen radicals. However, these radicals have a high energy, indicating that nitrogen gas plasma could be used to sterilize microorganisms and inactivate endotoxins. The sterilization mechanism of nitrogen gas plasma is the synergistic effect of a high rising-up voltage pulse, UV irradiation and atomic nitrogen radicals. Thus, the target cells were damaged by degradation, which resulted in death. The biological indicator (BI) used in this study was <I>Geobacillus stearothermophilus</I> ATCC 7953 at a population of 1×10<SUP>6</SUP> CFU/sheet. Sterility assurance was confirmed by using the Bl. Moreover, endotoxins were successfully inactivated. More than 5 log reduction of endotoxins could be attained with 30 minutes of nitrogen gas plasma exposure. Material functionality influenced by nitrogen gas plasma presented a satisfactory result. No deterioration of polymers could be observed by nitrogen gas plasma exposure.

Journal

  • Biocontrol Science

    Biocontrol Science 12(4), 131-143, 2007-12-10

    The Society for Antibacterial and Antifungal Agents, Japan

References:  33

Cited by:  16

Codes

  • NII Article ID (NAID)
    10020171466
  • NII NACSIS-CAT ID (NCID)
    AA11169621
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    13424815
  • Data Source
    CJP  CJPref  J-STAGE 
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