鼻腔悪性黒色腫症例に対する硼素中性子捕捉療法  [in Japanese] BNCT of Nasal Melanoma : A Case Report  [in Japanese]

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Author(s)

Abstract

Malignant melanoma developing in the mucosa of the nasal cavity and paranasal sinuses is rare and has an unfavorable prognosis. We report the clinical course of the first case treated by boron neutron capture therapy (BNCT) for nasal malignant melanoma and discuss several advantages of BNCT. The patient was a 55-year-old man with nasal malignant melanoma complaining of right nasal bleeding. He underwent a pre-irradiation CT scan for treatment planning that was performed with the “JCDS” software program. The tumor was irradiated at the Japan Atomic Energy Agency Research Reactor No. 4 (JRR4) with epithermal neutrons at 3.5MW for 44 minutes. The tumor dose and normal tissue dose calculated ranged from 16.0 to 21.2Gy and from 6.8 to 9.5Gy, respectively. There has been continuous complete regression in the tumor and no acute and chronic complications for 8 months up to the present. Although only one patient has shown a complete regression and additional long-term follow-up should be performed to assess this treatment, we believe that nasal malignant melanoma is suitable for BNCT and that such excellent results will have a great impact on patients in the near future.

Journal

  • Practica Oto-Rhino-Laryngologica

    Practica Oto-Rhino-Laryngologica 99(12), 1017-1022, 2006-12-01

    The Society of Practical Otolaryngology

References:  18

Codes

  • NII Article ID (NAID)
    10020336764
  • NII NACSIS-CAT ID (NCID)
    AN00107089
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    00326313
  • NDL Article ID
    8591913
  • NDL Source Classification
    ZS43(科学技術--医学--耳鼻咽喉科学)
  • NDL Call No.
    Z19-421
  • Data Source
    CJP  NDL  J-STAGE 
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