Extrapancreatic Proinsulin/Insulin-expressing Cells in Diabetes Mellitus: Is History Repeating Itself?

• KOJIMA Hideto

  Department of Molecular Genetics in Medicine, Shiga University of Medical Science Division of Diabetes, Endocrinology and Metabolism, Departments of Medicine and Molecular & Cellular Biology, Baylor College of Medicine

• FUJIMIYA Mineko

  Department of Anatomy, Shiga University of Medical Science

• TERASHIMA Tomoya

  Division of Diabetes, Endocrinology and Metabolism, Departments of Medicine and Molecular & Cellular Biology, Baylor College of Medicine

• KIMURA Hiroshi

  Department of Molecular Genetics in Medicine, Shiga University of Medical Science

• CHAN Lawrence

  Division of Diabetes, Endocrinology and Metabolism, Departments of Medicine and Molecular & Cellular Biology, Baylor College of Medicine

抄録

Insulin is a key regulator of life. Until 25 years ago, the pancreatic β-cell was thought to be the only organ that produces insulin in the body. Insulin deficiency, whether absolute (in type 1) or relative (in type 2 diabetes), underlies the metabolic derangements in diabetes mellitus, and investigations on insulin have concentrated on pancreatic insulin production, its regulation and the metabolic consequences of insulin deficiency. The thymus was the next organ that was found to also produce insulin, a process that may tolerize the body to the molecule, protecting the host from developing autoimmune β-cell destruction and (type 1) diabetes. However, now and then there were descriptions of promiscuous insulin production outside the pancreas. During our investigations on diabetes gene therapy in rodents, we serendipitously came across the presence of mysterious cells marked by proinsulin production in unexpected organs, some of which cells may underlie certain chronic diabetic complications. Starting with a historical perspective on insulin expression in brain and thymus, this review focuses mainly on unraveling the mystery of extrapancreatic extrathymic proinsulin/insulin expression in diabetes mellitus.<br>

収録刊行物

• Endocrine Journal

  Endocrine Journal 53 (6), 715-722, 2006

  一般社団法人 日本内分泌学会

キーワード

• Insulin
• Diabetes mellitus
• Islets
• Gene therapy
• Extrapancreatic

詳細情報

• CRID: 1390282681277232384
• NII論文ID: 10020612249
• NII論文ID: 130004443259
• NII書誌ID: AA10901436
• DOI: 10.1507/endocrj.kr-84
• ISSN: 13484540
• ISSN: 09188959
• Web Site: http://www.jstage.jst.go.jp/article/endocrj/53/6/53_6_715/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007191524
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可