Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population
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- HIROMATSU Yuji
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
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- FUKUTANI Tomoka
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
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- ICHIMURA Michiko
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
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- MUKAI Tokunori
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
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- KAKU Hiroo
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
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- MIYAKE Ikuyo
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
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- YAMADA Kentaro
- Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
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抄録
Graves' disease (GD) is an autoimmune disorder with genetic predisposition and frequently associated with Graves' ophthalmopathy (GO). Interleukin 12 (IL-12) is an important mediator of inflammatory immune responses and is expressed in the thyroid and orbit. IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33. The aim of the present study was to investigate whether IL-12B gene polymorphism is associated with the development of GD or GO. IL-12B gene polymorphism was studied in Japanese GD patients (n = 329) and healthy control subjects without anti-thyroid autoantibodies or a family history of autoimmune disorders (n = 226). The A/C polymorphism at position 1188 of the 3' untranslated region (3'UTR) of the IL-12B gene was analyzed using the polymerase chain reaction - restriction fragment length polymorphism method. There was no difference in allele or genotype frequency of the IL-12B gene polymorphism (1188A/C) between GD patients and control subjects. There was no association of the IL-12B gene polymorphism with ophthalmopathy, severity of hyperthyroidism or serum IgE levels. There was no association of the IL-12B gene polymorphism with serum IL-12 levels, which were significantly elevated in hyperthyroid phase of GD. In conclusion, IL-12B gene 1188A/C polymorphism is not associated with GD or GO susceptibility in Japanese.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 53 (6), 753-759, 2006
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390001206300518784
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- NII論文ID
- 10020612453
- 130004443265
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- NII書誌ID
- AA10901436
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- ISSN
- 13484540
- 09188959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可