Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

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  • HIROMATSU Yuji
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
  • FUKUTANI Tomoka
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
  • ICHIMURA Michiko
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
  • MUKAI Tokunori
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
  • KAKU Hiroo
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
  • MIYAKE Ikuyo
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine
  • YAMADA Kentaro
    Division of Endocrinology and Metabolism, Department of Medicine, Kurume University School of Medicine

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Abstract

Graves' disease (GD) is an autoimmune disorder with genetic predisposition and frequently associated with Graves' ophthalmopathy (GO). Interleukin 12 (IL-12) is an important mediator of inflammatory immune responses and is expressed in the thyroid and orbit. IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33. The aim of the present study was to investigate whether IL-12B gene polymorphism is associated with the development of GD or GO. IL-12B gene polymorphism was studied in Japanese GD patients (n = 329) and healthy control subjects without anti-thyroid autoantibodies or a family history of autoimmune disorders (n = 226). The A/C polymorphism at position 1188 of the 3' untranslated region (3'UTR) of the IL-12B gene was analyzed using the polymerase chain reaction - restriction fragment length polymorphism method. There was no difference in allele or genotype frequency of the IL-12B gene polymorphism (1188A/C) between GD patients and control subjects. There was no association of the IL-12B gene polymorphism with ophthalmopathy, severity of hyperthyroidism or serum IgE levels. There was no association of the IL-12B gene polymorphism with serum IL-12 levels, which were significantly elevated in hyperthyroid phase of GD. In conclusion, IL-12B gene 1188A/C polymorphism is not associated with GD or GO susceptibility in Japanese.<br>

Journal

  • Endocrine Journal

    Endocrine Journal 53 (6), 753-759, 2006

    The Japan Endocrine Society

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