Analysis of the Factors Contributing to Serum Retinol Binding Protein and Transthyretin Levels in Japanese Adults

• Yoshida Akihiro

  Department of Clinical Laboratory, Nakatsugawa Municipal Hospital

• Matsutani Yasuko

  Division of Nutrition & Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University

• Fukuchi Yoshiko

  Division of Nutrition & Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University

• Saito Kensuke

  Marketing Division, Dade Behring

• Naito Michitaka

  Division of Nutrition & Health, School and Graduate School of Life Studies, Sugiyama Jogakuen University

抄録

Objective: We examined various factors possibly related to metabolic syndrome, particularly focusing on nutritional assessment proteins such as retinol binding protein (RBP) and transthyretin (TTR), and remnant lipoproteins.<BR>Materials and Methods: Fasting serum lipid was analyzed in 58 Japanese adult volunteers (33 men and 25 women, 42.5 ± 10.1 years old).<BR>Results: The lipid profiles of the subjects were classified by lipoprotein polyacrylamide gel electrophoretic patterns into Types S (n=10), A (n=37), and N (n=11), according to the method described in Internal Medicine 42: 244, 2003. RBP and TTR were significantly higher in Type N than in Types S and A. In multivariate analysis, RBP was accounted for by remnant-like particle-triglyceride (RLP-TG), interleukin 6, body mass index and low-density lipoprotein (LDL)-cholesterol (adjusted R² =0.621). TTR was accounted for by lipoprotein(a), adiponectin and RLP-TG (adjusted R² =0.415). Malondialdehyde-LDL was significantly accounted for by LDL-cholesterol and RLP-cholesterol (adjusted R² =0.601). Lipoprotein(a) and LDL-cholesterol were independent variables for oxidized LDL antigen (adjusted R² =0.620). High-sensitivity C-reactive protein was accounted for by interleukin 6, immunoreactive insulin and oxidized LDL antigen (adjusted R² =0.361). Uric acid and body mass index were independent variables for adiponectin (adjusted R² =0.429).<BR>Conclusion: RBP and TTR may be useful as convenient and simple clinical markers of overnutrition and possibly of metabolic syndrome.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 13 (4), 209-215, 2006

  一般社団法人 日本動脈硬化学会

キーワード

• Remnant lipoprotein
• Retinol binding protein
• Overnutrition
• Metabolic syndrome

詳細情報

• CRID: 1390001204433274240
• NII論文ID: 130004444176
• NII論文ID: 10020627223
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.13.209
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://www.jstage.jst.go.jp/article/jat/13/4/13_4_209/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007085069
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可