Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy

• Nakagami Hironori

  Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

• Morishita Ryuichi

  Division of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan.

• Maeda Kazuhisa

  Medical Center for Translational Research, Osaka University Hospital, Osaka, Japan.

• Kikuchi Yasushi

  Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

• Ogihara Toshio

  Department of Geriatric Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

• Kaneda Yasufumi

  Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Osaka, Japan.

抄録

Adult stem cells hold great promise for use in tissue repair and regeneration, and the delivery of autologous progenitor cells into ischemic tissue is emerging as a novel therapeutic option. We and others have recently demonstrated the potential impact of adipose tissue-derived stromal cells (ADSC) on regenerative cell therapy for ischemic diseases. The main benefit of ADSC is that they can be easily harvested from patients by a simple, minimally invasive method and also easily cultured. Cultured ADSC can be induced to differentiate into not only adipocytes, but also bone, neurons or endothelial cells in certain conditions. Interestingly, they secrete a number of angiogenesis-related cytokines, such as vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), which might be suitable for regenerative cell therapy for ischemic diseases. In the ischemic mouse hindlimb, the angiogenic score was improved in the ADSC-treated group. Moreover, recent reports demonstrated that these ADSC can also be induced to differentiate into cardiac myocytes. These adipose tissue-derived cells have potential in angiogenic cell therapy for ischemic disease, and might be applied for regenerative cell therapy instead of bone marrow cells in the near future.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 13 (2), 77-81, 2006

  一般社団法人 日本動脈硬化学会

キーワード

• Adipose tissue
• Regenerative cell therapy
• Angiogenesis
• Growth factor

詳細情報

• CRID: 1390001204432733952
• NII論文ID: 130004444166
• NII論文ID: 10020627442
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.13.77
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://www.jstage.jst.go.jp/article/jat/13/2/13_2_77/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007142342
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可