A Novel Blood Pressure-independent Arterial Wall Stiffness Parameter; Cardio-Ankle Vascular Index (CAVI)

• Shirai Kohji

  Internal Medicine, Sakura Hospital, Medical Center, Toho University, Chiba, Japan.

• Utino Junji

  Mihama Clinics, Chiba, Japan.

• Otsuka Kuniaki

  Tokyo Women’s Medical University, Medical Center East, Tokyo, Japan.

• Takata Masanobu

  Toyama Teishin Hospital, Toyama, Japan.

抄録

To measure the stiffness of the aorta, femoral artery and tibial artery noninvasively, cardio-ankle vascular index (CAVI) which is independent of blood pressure was developed. The formula for measuring this index is;<BR>    CAVI=a{(2ρ/ΔP) × ln(Ps/Pd)PWV²} + b<BR>where, Ps and Pd are systolic and diastolic blood pressures respectively, PWV is pulse wave velocity between the heart and ankle, ΔP is Ps − Pd, ρ is blood density, and a and b are constants. This equation was derived from Bramwell-Hill’s equation¹⁾, and stiffness parameter²⁾.<BR>To elucidate the clinical utility of CAVI, the reproducibility and dependence on blood pressure were studied using VaSera (Fukuda Denshi Co., Ltd.). Furthermore, CAVI in hemodialysis patients with or without atherosclerotic diseases was measured.<BR>The average coefficient of variation for five measurements among 22 persons was 3.8%. In hemodialysis patients (n = 482), CAVI was correlated weakly with systolic and diastolic blood pressures (R = 0.175, 0.006), while brachial-ankle PWV was correlated strongly with systolic and diastolic blood pressures (R = 0.463, 0.335). CAVI in hemodialysis patients without signs of atherosclerotic diseases (NA) was 8.1 ± 0.3 (mean ± SD). That in patients receiving percutaneous transluminal coronary angioplasty was 8.8 ± 0.3 (p < 0.05 vs. NA). CAVI in patients with ischemic change in their electrocardiogram (ECG) was 8.5 ± 0.3 (p < 0.05 vs. NA). That in patients with diabetes mellitus was 8.5 ± 0.3 (p < 0.002 vs. NA). CAVI in the patients with all three complications was 8.9 ± 0.35 (p < 0.001 vs. NA). These results suggested that CAVI could reflect arteriosclerosis of the aorta, femoral artery and tibial artery quantitatively.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 13 (2), 101-107, 2006

  一般社団法人 日本動脈硬化学会

キーワード

• Arteriosclerosis
• PWV
• CAVI
• Hemodialysis
• Stiffness parameter
• Vascular function

詳細情報

• CRID: 1390001204432555904
• NII論文ID: 130004444162
• NII論文ID: 10020627545
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.13.101
• COI: 1:STN:280:DC%2BD28zgsFGhsQ%3D%3D
• ISSN: 18803873
• ISSN: 13403478
• ISSN: http://id.crossref.org/issn/13403478
• PubMed: 16733298
• Web Site: https://www.jstage.jst.go.jp/article/jat/13/2/13_2_101/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2007142346
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
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