ガスクロマトグラフィー質量分析による標準物質を必要としない乱用薬物一斉分析法の開発 Development of a Systematic Screening Procedure for Abused Drugs without Using Standard Compounds by Gas Chromatography/Mass Spectrometry

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著者

    • 工藤 恵子 KUDO Keiko
    • 九州大学大学院医学研究院法医学分野 Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University
    • 石田 知己 ISHIDA Tomomi
    • 九州大学大学院医学研究院法医学分野 Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University
    • 池田 典昭 IKEDA Noriaki
    • 九州大学大学院医学研究院法医学分野 Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University

抄録

In this paper, we describe our approach to developing a systematic screening procedure for abused drugs that does not require the use of standard compounds. This procedure uses gas chromatography/mass spectrometry (GC/MS) with retention time locking. Fifty-five abused drugs, including amphetamine, piperazine, tryptamine and phenetylamine derivatives, opiates, and benzodiazepines, were selected as target compounds. The method consists of solid-phase extraction with a polar-enhanced Focus<sup>TM</sup> column followed by acetylation and GC/MS with retention time locking. Based on this method, an “abused drugs database,” which includes the retention time, qualifier ion/target ion percentage, and calibration curve (values of slope and intercept), was constructed using the novel GC/MS software, NAGINATA<sup>TM</sup>. Using this database, we found a significant improvement in the data analysis time, and qualitative and quantitative information about each drug was obtained without using standard compounds. The practical applications for examining urine samples in forensic cases are also presented.

収録刊行物

  • 質量分析 = Mass spectroscopy

    質量分析 = Mass spectroscopy 56(3), 123-130, 2008-06-01

    一般社団法人 日本質量分析学会

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各種コード

  • NII論文ID(NAID)
    10021086843
  • NII書誌ID(NCID)
    AN0010555X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    13408097
  • NDL 記事登録ID
    9541323
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z17-213
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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