新しい質量分析技術の法医学領域への応用  [in Japanese] Application of New Mass Spectrometric Techniques to Legal Medicine  [in Japanese]

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Author(s)

    • 石井 晃 ISHII Akira
    • 名古屋大学大学院医学系研究科法医・生命倫理学 Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine
    • 金子 理奈 KANEKO Rina
    • 藤田保健衛生大学医学部法医学教室 Department of Legal Medicine, Fujita Health University School of Medicine
    • 浜島 誠 HAMAJIMA Makoto
    • 藤田保健衛生大学医学部法医学教室 Department of Legal Medicine, Fujita Health University School of Medicine

Abstract

In the fields of legal medicine and forensic toxicology, numerous drugs and poisons obtained from diverse biological specimens such as whole blood, urine, and hair need to be identified and quantified. Therefore, it is necessary to develop new methods for analysis of drugs, especially mass spectrometric methods. In this paper, we introduce three methods—surface ionization organic mass spectrometry, a combination of mass spectrometry and cryogenic oven trapping (COT), and laser spray ionization (LSI)—and their application to legal medicine. Gas chromatography/surface ionization organic mass spectrometry is very sensitive in detecting drugs containing tertiary amine residues; for Phencyclidine (PCP), its sensitivity is 20 to 1,000 times higher than that of the conventional electron ionization method. Surface ionization organic mass spectrometry is suitable for compounds containing cyclic tertiary amino side chains. COT in combination with gas chromatography has enabled detection of many volatile organic compounds (VOCs) with high sensitivity. We have succeeded in quantifying several VOCs, such as chloroform, cyanide, thinner components, ethanol, and general anesthetics in whole blood by COT; COT affords a sensitivity that is 10 to 50 times higher than that of the conventional headspace gas chromatography method. Recently, we succeeded in identifying and quantifying 15 VOCs in human whole blood with the combination of COT and mass spectrometry. LSI is a new ionization method for liquid chromatography/mass spectrometry. We have succeeded in detecting aconitine alkaloids and psychopharmaceuticals using LSI. In the infusion mode, aconitine and haloperidol were ionized with higher efficiency compared to that in the conventional electrospray mode. However, since the signals in the LSI mode are not stable, it is necessary to improve the stability of signals in the LSI mode for applying LSI to forensic toxicology.

Journal

  • Journal of the Mass Spectrometry Society of Japan

    Journal of the Mass Spectrometry Society of Japan 56(3), 131-138, 2008-06-01

    The Mass Spectrometry Society of Japan

References:  46

  • <no title>

    法務省法務総合研究所編

    犯罪白書 平成19年度版, 115, 2007

    Cited by (1)

  • <no title>

    警察庁編

    警察白書 平成19年度版, 130, 2007

    Cited by (1)

  • <no title>

    SUZUKI O.

    Forensic Sci. Int. 113, 331, 2000

    Cited by (1)

  • <no title>

    LANGMUIR I.

    Proc. R. Soc. A 107, 61, 1925

    Cited by (1)

  • <no title>

    ZANDBERG E. Ya.

    Russ. Chem. Rev. 51, 819, 1982

    Cited by (1)

  • <no title>

    FUJII T.

    Int. J. Mass Spectrom. Ion Processes 57, 63, 1984

    Cited by (1)

  • <no title>

    FUJII T.

    Eur. Mass Spectrom. 2, 91, 1996

    Cited by (1)

  • <no title>

    SENO H.

    Jpn. J. Legal Med. 47, 367, 1993

    Cited by (1)

  • <no title>

    ISHII A.

    J. Forensic Sci. 40, 483, 1995

    Cited by (1)

  • <no title>

    ISHII A.

    Int. J. Legal Med. 108, 244, 1996

    Cited by (1)

  • <no title>

    HATTORI H.

    Jpn. J. Forensic Toxicol. 12, 26, 1994

    Cited by (1)

  • <no title>

    SENO H.

    J. Mass Spectrom. 35, 33, 2000

    Cited by (1)

  • <no title>

    ISHII A.

    J. Chromatogr. B 758, 117, 2001

    Cited by (1)

  • <no title>

    ISHII A.

    Jpn. J. Forensic Toxicol. 17, 195, 1999

    Cited by (1)

  • <no title>

    ISHII A.

    Surface Ionization and Its Application to GC-MS : The Encyclopedia of Mass Spectrometry 8, 92, 2006

    Cited by (1)

  • <no title>

    STEAD A. H.

    Hum. Toxicol. 3, 437, 1983

    Cited by (1)

  • <no title>

    WATANABE-SUZUKI K.

    J. Chromatogr. B 727, 89, 1999

    Cited by (1)

  • <no title>

    LEE X.-P.

    Analyst 123, 147, 1998

    Cited by (1)

  • <no title>

    KOJIMA T.

    J. Chromatogr. B 762, 103, 2001

    Cited by (1)

  • <no title>

    金子理奈

    第32回日本医用マススペクトル学会抄録集, 2007, 2007

    Cited by (1)

  • <no title>

    HIRAOKA K.

    Rapid Commun. Mass Spectrom. 12, 1170, 1998

    Cited by (1)

  • <no title>

    HIRAOKA K.

    J. Mass Spectrom. 39, 341, 2004

    Cited by (1)

  • <no title>

    KANEKO R.

    J. Mass Spectrom. 41, 810, 2006

    Cited by (1)

  • <no title>

    KANEKO R.

    Abstract of Joint Meeting SOFT and TIAFT, Washington D.C., 2004, 2004

    Cited by (1)

  • 第91次日本法医学会総会

    石井晃

    日本法医学会雑誌 61, 70, 2007

    Cited by (1)

  • <no title>

    RASULEV U. Kh.

    Prog. Surf. Sci. 28, 181, 1988

    Cited by (1)

  • <no title>

    FUJII T.

    Anal. Chem. 57, 2625, 1985

    Cited by (5)

  • <no title>

    HATTORI H.

    J. Chromatogr. 529, 189, 1990

    Cited by (2)

  • <no title>

    HATTORI H.

    J. Chromatogr. 579, 247, 1992

    Cited by (3)

  • <no title>

    HATTORI H.

    J. Chromatogr. 564, 278, 1991

    Cited by (2)

  • <no title>

    YAMAMOTO S.

    Jpn. J. Forensic Toxicol. 9, 41, 1991

    Cited by (2)

  • <no title>

    SENO H.

    Jpn. J. Forensic Toxicol. 10, 241, 1992

    Cited by (2)

  • <no title>

    HATTORI H.

    Jpn. J. Forensic Toxicol. 11, 31, 1993

    Cited by (3)

  • <no title>

    HATTORI H

    J. Chromatogr. A 674, 15, 1994

    Cited by (3)

  • <no title>

    ISHII A.

    Chromatographia 43, 331, 1996

    Cited by (4)

  • <no title>

    WATANABE K.

    Chromatographia 44, 55, 1997

    Cited by (1)

  • <no title>

    ISHII A.

    Marangoni Convection Modeling Research Annual Report (NASDA-TMR-000006E) Chap. 2.2, 115, 2000

    Cited by (2)

  • <no title>

    ISHII A

    Anal. Chem. 72(2), 404, 2000

    Cited by (3)

  • <no title>

    FUJII T.

    J. Mass Spectrom. Ion Processes 79, 221, 1987

    Cited by (2)

  • <no title>

    FUJII T.

    J. Chromatogr. B 687, 395, 1996

    Cited by (1)

  • <no title>

    ISHII A.

    J. Chromatogr. B 776, 3, 2002

    Ichushi Web  Cited by (1)

  • <no title>

    WATANABE K

    Anal. Chem. 69, 5178, 1997

    Cited by (2)

  • <no title>

    ISHII A

    Anal. Chem. 70, 4873, 1998

    Cited by (5)

  • <no title>

    SETO Y.

    Archiv. Biochem. Biophys. 321, 245, 1995

    Cited by (3)

  • Sensitive determination of xylenes in whole blood by capillary gas chromatography with cryogenic trapping

    HATTORI H. , IWAI M. , KURONO S. , YAMADA T. , WATANABE SUZUKI K. , ISHII A. , SENO H. , SUZUKI O.

    J. Chromatogr. B 718(2), 285-289, 1998-11-06

    References (12) Cited by (2)

  • <no title>

    HIRAOKA K.

    Rapid Commun. Mass Spectrom. 11, 474, 1997

    Cited by (2)

Codes

  • NII Article ID (NAID)
    10021086864
  • NII NACSIS-CAT ID (NCID)
    AN0010555X
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    13408097
  • NDL Article ID
    9541350
  • NDL Source Classification
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL Call No.
    Z17-213
  • Data Source
    CJP  NDL  J-STAGE 
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