An Accurate Quantitative Analysis of Polymorphic Content by Chemometric X-ray Powder Diffraction
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- SUDA Masafumi
- Department of Pharmaceutics, Hoshi University
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- TAKAYAMA Kozo
- Department of Pharmaceutics, Hoshi University
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- OTSUKA Makoto
- Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University
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Data from X-ray powder diffraction (XRD) were subjected to a partial least-squares regression analysis (PLS) to build a calibration model for predicting the polymorphic content of carbamazepine (CBZ). The effectiveness of the PLS method in the construction of calibration models was analyzed by a scientific approach based on a regulation vector. CBZ forms I and III were characterized by differential scanning calorimetry (DSC) and XRD. Powder mixtures of forms I and III at various ratios (0 - 100% w/w; form III) were subjected to XRD. Five diffraction peaks were used for the peak-area method to compare with PLS. The results obtained by PLS had a better predictive accuracy compared to those of the peak-area method. The XRD-PLS method was established as a non-destructive, non-contact way to avoid the particle orientation effect based on statistical theory.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 24 (4), 451-457, 2008
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204256454400
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- NII論文ID
- 10021099447
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 9452041
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可