線条体における自発カルシウム濃度変化  [in Japanese] Spontaneous calcium changes in striatal cells  [in Japanese]

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Author(s)

    • 小山内 実 OSANAI Makoto
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 矢口 雄一 YAGUCHI Yuichi
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 山田 尚宏 [他] YAMADA Naohiro
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 大星 文人 OBOSHI Fumito
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 八木 哲也 YAGI Tetsuya
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University

Abstract

The striatum plays an important role in linking cortical activity to basal ganglia outputs. We conducted the calcium (Ca<sup>2+</sup>) imaging to investigate the spontaneous activities of the striatum using acute slice preparations. The corticostriatal slices of rats were stained with Fura-PE3-AM. Long lasting spontaneous intracellular Ca<sup>2+</sup> ([Ca<sup>2+</sup>]<sub>i</sub>) changes, which lasted up to several hundreds seconds, were observed. The amplitudes and the intervals of the changes were variable even in a single cell. Most cells exhibited irregular frequencies, but some exhibited oscillatory features. Most of these [Ca<sup>2+</sup>]<sub>i</sub> changes were not suppressed by TTX, blocker of action potentials. The number of the active cells, which exhibited the [Ca<sup>2+</sup>]<sub>i</sub> changes, was greatly reduced by the intracellular Ca<sup>2+</sup> store depletor, thapsigargin. Therefore, the intracellular Ca<sup>2+</sup> store is likely to contribute to the [Ca<sup>2+</sup>]<sub>i</sub> transients.<br>The [Ca<sup>2+</sup>]<sub>i</sub> changes under standard ACSF and TTX showed different levels of regularity. We tested synchronization of the [Ca<sup>2+</sup>]<sub>i</sub> changes between cell pairs under the both conditions. The number of synchronized cell pairs reduced in TTX. These results suggested that TTX insensitive and slow rate [Ca<sup>2+</sup>]<sub>i</sub> changes might exert the information processing in the striatum.

Journal

  • IEEJ Transactions on Electronics, Information and Systems

    IEEJ Transactions on Electronics, Information and Systems 128(7), 1050-1057, 2008-07-01

    The Institute of Electrical Engineers of Japan

References:  29

Cited by:  3

Codes

  • NII Article ID (NAID)
    10021132986
  • NII NACSIS-CAT ID (NCID)
    AN10065950
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    03854221
  • NDL Article ID
    9563538
  • NDL Source Classification
    ZN31(科学技術--電気工学・電気機械工業)
  • NDL Call No.
    Z16-795
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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