腫瘍細胞のアミノ酸トランスポーターの発現とそれを標的とした診断と治療への応用の可能性  [in Japanese] Expression of Amino Acid Transporters in Cancers and Their Application to Cancer Diagnosis and Therapuitics  [in Japanese]

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Author(s)

    • 金井 好克 KANAI Yoshikatsu
    • 大阪大学 大学院医学系研究科 生体システム薬理学 Division of Bio-system Pharmacology, Department of Pharmacology Graduate School of Medicine, Osaka University

Abstract

Amino acid transporters are integrated membrane proteins that provide cells with nutrient amino acids. It is well established that subsets of amino acid transporters are highly expressed in cancers. A system L transporter LAT1 exhibits prominent expression in many cancers and its expression is inversely correlated with prognosis in some cancers. LAT1 is responsible for the uptake of large neutral amino acids including several essential amino acids. Functional coupling with ASCT2 which is also upregulated in cancers seems beneficial for LAT1 to be driven by intracellular glutamine accumulated by ASCT2 via an exchange mechanism. Now it has been demonstrated that a LAT1- selective ligand, L-[3-18F]-α-methyltyrosine (18F-FMT), is accumulated selectively in cancers in humans in a positron emission tomography (PET) in LAT1-depndent manner. [18F]FMT-PET can be a realistic diagnostic tool in the future. As expected from the roles of LAT1 in cancers, the inhibition of LAT1 results in the suppression of cancers. The newly developed high-affinity inhibitors of LAT1 are expected with therapeutic usefulness.

Journal

  • MEMBRANE

    MEMBRANE 33(3), 108-117, 2008-05-01

    THE MEMBRANE SOCIETY OF JAPAN

References:  30

Codes

  • NII Article ID (NAID)
    10021167462
  • NII NACSIS-CAT ID (NCID)
    AN0023215X
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    03851036
  • NDL Article ID
    9525565
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z18-1127
  • Data Source
    CJP  NDL  J-STAGE 
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