ＤＮＡテンプレート有機合成去（ＤＴＳ）：生命原理に学ぶ機能性分子創製・探索への新規アプローチ

DOI Web Site 参考文献26件
  • 桜井 香里
    東京農工大学大学院共生科学技術研究院
  • Liu David R.
    Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology

書誌事項

タイトル別名
  • DNA-Templated Organic Synthesis (DTS): A Novel Approach to the Discovery of Functional Small Molecules Based on Nature's Evolutionary Principles
  • DNA テンプレート ユウキ ゴウセイホウ DTS セイメイ ゲンリ ニ マナブ キノウセイ ブンシ ソウセイ タンサク エノ シンキ アプローチ

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抄録

DNA-templated organic synthesis (DTS) has recently emerged as a general approach to translate DNA sequences into DNA-linked synthetic small molecules. DNA templates not only direct chemistries to construct small molecules but also serve as amplifiable encodings used to identify the chemical structures of the small molecules. Therefore, through DTS, synthetic small molecules can now be subjected to in vitro selection methods for the discovery of novel functional molecules. In this account, we describe the early efforts conducted in the Liu Laboratory to develop key technologies in DTS and new findings toward exploring the potential of a selection-based approach to the discovery of functional small molecules.

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