胎児期のアルコール曝露の影響に関する前向きコホート研究の動向と少量飲酒が子どもの身体発育に及ぼす影響についての系統的レビュー

• 須藤 紀子

  国立保健医療科学院生涯保健部

• 佐藤 加代子

  国立保健医療科学院生涯保健部

書誌事項

タイトル別名

• Review of Prospective Cohort Studies on the Effect of Prenatal Alcohol Exposure and on the Effect of Light Drinking on Children's Somatic Growth
• タイジキ ノ アルコール バクロ ノ エイキョウ ニ カンスル マエムキ コホート ケンキュウ ノ ドウコウ ト ショウリョウ インシュ ガ コドモ ノ シンタイ ハツイク ニ オヨボス エイキョウ ニ ツイテ ノ ケイトウテキ レビュー

抄録

A systematic review of prospective cohort studies published in 1968-2004 was conducted to provide information on the effect of prenatal alcohol exposure. Since the risk of light drinking is controversial, we also reviewed selected studies that assessed the effect of consuming less than 14g of absolute alcohol per day. Literature searches of the Medline and Igakuchuozasshi database yielded 652 citations in total. By scanning the titles and reading the abstracts, we were able to exclude 565 papers on animal studies, studies assessing alcohol consumption by recall, casecontrol studies, case reports, meta-analyses and proceedings, studies not quantitatively assessing alcohol consumption, studies on binge drinking, and narrative reviews and proceedings. The remaining 87 papers were read in full, and a further 30 were excluded based on the foregoing exclusion criteria. In total, 57 cohort studies were reviewed. The reported effects of prenatal alcohol exposure varied, with growth retardation, congenital anomalies, morphological brain abnormalities, sleep disturbance, neurological dysfunction, cognitive dysfunction, low IQ, learning difficulties, attention deficit, and behavioral problems being reported. The effects of light drinking on children's somatic growth were inconsistent. Meta-analyses for each effect need to be conducted to establish evidence-based guidelines for drinking during pregnancy. The present indications are that light drinking during pregnancy should be avoided due to lack of evidence that it is safe.

収録刊行物

• 栄養学雑誌

  栄養学雑誌 63 (5), 291-299, 2005

  特定非営利活動法人 日本栄養改善学会

キーワード

• 妊娠中の飲酒
• 胎児期のアルコール曝露
• コホート研究
• 系統的レビュー

詳細情報

• CRID: 1390001206548337792
• NII論文ID: 130003667848
• NII論文ID: 10021177907
• NII論文ID: 10018275398
• NII書誌ID: AN00023058
• DOI: 10.5264/eiyogakuzashi.63.291
• ISSN: 18837921
• ISSN: 00215147
• NDL書誌ID: 7709700
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I7709700
• Web Site: https://search.jamas.or.jp/link/ui/2006075243
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可