Subacute Encephalitis associated with Anti-Glutamate receptor antibodies: Serial studies of MRI, 1H-MRS and SPECT

• Yamamoto Shiro

  Cerebrovascular Division, Department of Medicine, Yodogawa Christian Hospital

• Koide Yasumichi

  Cerebrovascular Division, Department of Medicine, Yodogawa Christian Hospital National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders

• Fujiwara Mito

  Cerebrovascular Division, Department of Medicine, Yodogawa Christian Hospital

• Nakazawa Kenichiro

  Department of Neurology, Yodogawa Christian Hospital

• Takahashi Yukitoshi

  National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders

• Hara Hitoshi

  Cerebrovascular Division, Department of Medicine, Yodogawa Christian Hospital

Bibliographic Information

Other Title

• 抗グルタミン酸受容体抗体陽性を示した亜急性脳炎の１例：ＭＲＩ・｀１´Ｈ‐ＭＲＳ・ＳＰＥＣＴの経時的変化からの検討
• 症例報告 抗グルタミン酸受容体抗体陽性を示した亜急性脳炎の1例--MRI・1H-MRS・SPECTの経時的変化からの検討
• ショウレイ ホウコク コウグルタミンサン ジュヨウタイ コウタイ ヨウセイ オ シメシタ アキュウセイ ノウエン ノ 1レイ MRI 1H MRS SPECT ノ ケイジテキ ヘンカ カラノ ケントウ

Abstract

A 32-year-old man who had experienced fever and a pulsating headache of the right occipital region for a month and a transient left hemianopia and numbness in the left arm two weeks prior to presentation was admitted to our hospital because of a seizure. Fluid-attenuated inversion recovery and diffusion-weighted magnetic resonance imaging (MRI) showed high-intensity signals, without reduction of apparent diffusion coefficient value, in the right temporo-occipital cortices. Proton MR spectroscopy (¹H-MRS) indicated a decrease in N-acetyl-aspartate, and single-photon emission CT (SPECT) showed hyperperfusion in the right temporo-occipital territory. An examination of the cerebrospinal fluid showed an elevation of mononuclear cells and the presence of anti-glutamate ε2 receptor antibodies. All abnormalities shown by these imaging techniques were normalized in the clinical course. This report suggests that MRI, ¹H-MRS and SPECT studies were useful in understanding the pathogenesis of encephalitis associated with glutamate receptor antibodies.<br>

Journal

• Rinsho Shinkeigaku

  Rinsho Shinkeigaku 48 (3), 196-201, 2008

  Societas Neurologica Japonica

Keywords

• encephalitis
• anti-glutamate receptor antibodies
• MR spectroscopy
• single photon emission CT

Details

• CRID: 1390001205036649344
• NII Article ID: 10021187316
• NII Book ID: AN00253207
• DOI: 10.5692/clinicalneurol.48.196
• ISSN: 18820654
• ISSN: 0009918X
• NDL BIB ID: 9421110
• Web Site: http://id.ndl.go.jp/bib/9421110
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9421110
• Web Site: https://search.jamas.or.jp/link/ui/2008178253
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed