NF-.KAPPA.B as a therapeutic target of rheumatoid arthritis

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  • OKAMOTO Takashi
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences
  • TSUCHIYA Atsushi
    Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences

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  • 関節リウマチの治療標的としてのＮＦ－κＢ

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Abstract

  Nuclear factor kappa B (NF-κB) is an inducible transcription factor that is activated through intracellular signal transduction pathways. Its target genes include those that are responsible for immuno-inflammatory responses, apoptosis inhibitors, growth promoting factors, virus-encoded proteins involved in viral replication, and self-regulatory proteins for NF-κB actions. Thus, it has been reported that NF-κB plays major roles in the pathogenesis of cancer, leukemia, autoimmune diseases such as rheumatoid arthritis, and AIDS. On the other hand, it has been revealed that some drugs that are effective in the treatment of rheumatoid arthritis have actually inhibitory activities of NF-κB actions. In this review, we have attempted to analyze various pathological steps of rheumatoid arthritis especially by depicting the steps that involve NF-κB. We also discuss possible therapeutic strategies with NF-κB as a major target.<br>

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