Human Th17 Cell Clones and Natural Immune Responses

• Matsushita Sho

  Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University

• Higashi Takehiro

  Department of Allergy and Immunology, Faculty of Medicine, Saitama Medical University

Abstract

Immunomodulators such as lipopolysaccharides (LPS) and forskolin change the nature of dendritic cells (DCs) to induce Th1 and Th2 cells, respectively, thereby designated Th1 or Th2 adjuvants. Recent studies showed that Th17-inducing activity can be carried by certain polysaccharides such as β-glucan derived from Candia albicans. Such activities can be scrutinized by using MLR, cAMP and possibly, differential expression of Notch ligand isoforms. In this review article, we also introduce an effective method to establish human Th17 cell clones and a transcriptome analysis using human Th subpopulations. In vivo relevance to human Th17 responses is discussed.<br>

Journal

• Allergology International

  Allergology International 57 (2), 135-140, 2008

  Japanese Society of Allergology

Keywords

• adjuvant
• cAMP
• dendritic cells
• Notch ligand
• Th17

Details

• CRID: 1390001204632088448
• NII Article ID: 10021246514
• NII Article ID: 130004476966
• NII Book ID: AA11091750
• DOI: 10.2332/allergolint.r-08-162
• ISSN: 14401592
• ISSN: 13238930
• PubMed: 18427166
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015307644?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015307644?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2008357967
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed