Activin A: Autocrine Regulator of Kidney Development and Repair

DOI Web Site 9 Citations 125 References
  • MAESHIMA Akito
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • MIYA Masaaki
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • MISHIMA Keiichiro
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • YAMASHITA Shin
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine
  • KOJIMA Itaru
    Department of Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University
  • NOJIMA Yoshihisa
    Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine

Search this article

Abstract

The research described in this review suggests a novel and important role for activin A in the developmental and repair processes of the kidney (Table 1). The results obtained in these studies indicate that activin A is a negative regulator of kidney development and plays an essential part in kidney diseases, such as acute renal failure or renal fibrosis. It is also possible that activin A is a key player in the pathophysiological processes of other kidney diseases, such as congenital urogenital abnormalities, renal cystic disease and renal cell carcinoma. Activin A is thus a potential target for therapeutic interventions in kidney diseases. To address this issue, more detailed analysis on the regulation of activin production, modulation of activin activity and activin target genes is required.<br>

Journal

Citations (9)*help

See more

References(125)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top