Expression and Regulation of Periostin/OSF-2 Gene in Rat Uterus and Human Endometrium

DOI Web Site 参考文献40件
  • HIROI Hisahiko
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • MOMOEDA Mikio
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • NAKAZAWA Fumiko
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • KOIZUMI Minako
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • TSUTSUMI Ryo
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • HOSOKAWA Yumi
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • OSUGA Yutaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • YANO Tetsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • TSUTSUMI Osamu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo
  • TAKETANI Yuji
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo

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Periostin/OSF2 is a ligand for αvβ3 and αvβ5 integrins and activates the Akt/PKB pathway. Recent reports of periostin/OSF2 gene disrupted mice indicate that periostin/OSF-2 plays an important role in implantation. Quantitative RT-PCR revealed that the expression of periostin/OSF-2 mRNA in rat uteri was reduced to approximately 10% at 12 h after 17β-estradiol (E2) injection, but was not changed after progesterone (P) injection. RT-PCR revealed the expression of periostin/OSF-2 in human endometrium, cultured human endometrial stromal cells (ESCs), and cultured human endometrial epithelial cells. In ESCs, the expression of periostin/OSF-2 mRNA was reduced to approximately 50% at 6 h after E2 treatment. The amount of periostin/OSF2 mRNA in human endometrium significantly increased during mid-proliferative and early secretory phases of menstrual cycle, and decreased during late-proliferative, mid-secretory and late secretory phases. The expression of periostin/OSF2 mRNA significantly decreased in ESCs decidualized by treatment with E2 and P for 7 and 11 days. By immunohistochemistry, the expression of periostin/OSF-2 was strongly detected in endometrial stromal cells during early proliferative, mid-proliferative and early secretory phases, and was strongly detected in endometrial epithelial cells during late secretory phase. This study demonstrated that the expression of periostin/OSF-2 is regulated by ovarian steroid hormones in rat uterus and human endometrium.<br>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 55 (1), 183-189, 2008

    一般社団法人 日本内分泌学会

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