The -1535 Promoter Variant of The Visfatin Gene Is Associated with Serum Triglyceride and HDL-cholesterol Levels in Japanese Subjects
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- TOKUNAGA Ayumi
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- MIURA Atsuko
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- OKAUCHI Yukiyoshi
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- SEGAWA Katsumori
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- FUKUHARA Atsunori
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- OKITA Kohei
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- TAKAHASHI Masahiko
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- FUNAHASHI Tohru
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- MIYAGAWA Jun-ichiro
- Division of Diabetes & Metabolism, Internal Medicine, Hyogo College of Medicine
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- SHIMOMURA Iichiro
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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- YAMAGATA Kazuya
- Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
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Visfatin is a novel adipocytokine that is expressed by the visceral fat cells. We investigated the role of genetic variation in the visfatin gene in the pathophysiology of type 2 diabetes and clinical variables in Japanese subjects. The 11 exons, and the promoter region of the visfatin gene were screened for single nucleotide polymorphisms (SNPs) by PCR-direct sequencing. We found SNPs in the promoter region (SNP - 1535T>C), exon 2 (SNP + 131C>G, Thr44Arg), and exon 7 (SNP + 903G>A). The allele and genotype frequencies of these SNPs showed no significant differences between 200-448 diabetic and 200-333 control subjects. However, the -1535T/T genotype was associated with lower serum triglyceride levels (T/T vs. T/C + C/C (p = 0.015) and T/T vs. C/C (p = 0.043)) and higher HDL-cholesterol levels (T/T vs. C/C, p = 0.0496) in the nondiabetic subjects. Reporter gene assay of 3T3-L1 adipocytes revealed that the promoter activity of -1535T and -1535C was similar, suggesting that the observed association may reflect linkage disequilibrium between -1535T>C and causative variations of the visfatin gene.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 55 (1), 205-212, 2008
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681275711744
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- NII論文ID
- 10021265064
- 130004443369
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- NII書誌ID
- AA10901436
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- ISSN
- 13484540
- 09188959
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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